Olfactomedin 2

Olfactomedin 2, also known as noelin 2, is a protein that in humans is encoded by the OLFM2 gene.

OLFM2
Identifiers
Aliases	OLFM2, NOE2, NOELIN2, NOELIN2_V1, OlfC, olfactomedin 2
External IDs	OMIM: 617492; MGI: 3045350; HomoloGene: 14380; GeneCards: OLFM2; OMA:OLFM2 - orthologs
Gene location (Human) Chr. Chromosome 19 (human) Band 19p13.2 Start 9,853,718 bp End 9,936,515 bp
Gene location (Mouse) Chr. Chromosome 9 (mouse) Band 9|9 A3 Start 20,578,986 bp End 20,657,645 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence ventricular zone cingulate gyrus anterior cingulate cortex right frontal lobe Brodmann area 9 prefrontal cortex amygdala skin of leg caudate nucleus Top expressed in visual cortex primary visual cortex superior frontal gyrus habenula dorsomedial hypothalamic nucleus lumbar subsegment of spinal cord primary motor cortex prefrontal cortex cingulate gyrus piriform cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component cytoplasm synaptic membrane extracellular region cell junction AMPA glutamate receptor complex synapse membrane nucleus nucleoplasm glutamatergic synapse extrinsic component of synaptic membrane Biological process positive regulation of smooth muscle cell differentiation locomotory behavior visual perception protein secretion regulation of vascular associated smooth muscle cell dedifferentiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 93145 244723 Ensembl ENSG00000105088 ENSMUSG00000032172 UniProt O95897 Q8BM13 RefSeq (mRNA) NM_058164 NM_001304347 NM_001304348 NM_173777 NM_001357635 NM_001357639 RefSeq (protein) NP_001291276 NP_001291277 NP_477512 NP_776138 NP_001344564 NP_001344568 Location (UCSC) Chr 19: 9.85 – 9.94 Mb Chr 9: 20.58 – 20.66 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Further reading

• Funayama T, Mashima Y, Ohtake Y, et al. (2007). "SNPs and interaction analyses of noelin 2, myocilin, and optineurin genes in Japanese patients with open-angle glaucoma". Invest. Ophthalmol. Vis. Sci. 47 (12): 5368–75. doi:10.1167/iovs.06-0196. PMID 17122126.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Mukhopadhyay A, Talukdar S, Bhattacharjee A, Ray K (2004). "Bioinformatic approaches for identification and characterization of olfactomedin related genes with a potential role in pathogenesis of ocular disorders". Mol. Vis. 10: 304–14. PMID 15123989.
• Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19". Nature. 428 (6982): 529–35. Bibcode:2004Natur.428..529G. doi:10.1038/nature02399. PMID 15057824.
• Tomarev SI, Wistow G, Raymond V, et al. (2003). "Gene expression profile of the human trabecular meshwork: NEIBank sequence tag analysis". Invest. Ophthalmol. Vis. Sci. 44 (6): 2588–96. doi:10.1167/iovs.02-1099. PMID 12766061.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Yu W, Andersson B, Worley KC, et al. (1997). "Large-Scale Concatenation cDNA Sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
• Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.