p120 catenin

CTNND1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3L6X, 3L6Y
Identifiers
Aliases	CTNND1, CAS, CTNND, P120CAS, P120CTN, p120, p120(CAS), p120(CTN), catenin delta 1, BCDS2
External IDs	OMIM: 601045; MGI: 105100; HomoloGene: 1017; GeneCards: CTNND1; OMA:CTNND1 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	57,819,546 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	84,481,109 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; mucosa of esophagus; ; epithelium of colon; ; placenta; ; skin of abdomen; ; skin of leg; ; rectum; ; body of pancreas; ; minor salivary glands; ; sural nerve;
	Top expressed in
	tail of embryo; ; genital tubercle; ; ovary; ; jejunum; ; placenta; ; ileum; ; colon; ; lip; ; esophagus; ; lung;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; signaling receptor binding; protein kinase binding; cell adhesion molecule binding; cadherin binding;
Cellular component	cytoplasm; cytosol; membrane; cell-cell junction; growth cone; plasma membrane; dendritic spine; synapse; midbody; zonula adherens; extracellular exosome; nucleus; lamellipodium; catenin complex; Schaffer collateral - CA1 synapse; hippocampal mossy fiber to CA3 synapse; presynaptic active zone cytoplasmic component; glutamatergic synapse; postsynaptic density, intracellular component;
Biological process	regulation of transcription, DNA-templated; Wnt signaling pathway; transcription, DNA-templated; brain development; cell adhesion; adherens junction organization; negative regulation of canonical Wnt signaling pathway; entry of bacterium into host cell; cell-cell adhesion; cell-cell junction assembly; regulation of postsynaptic membrane neurotransmitter receptor levels;
	Sources:Amigo / QuickGO
Orthologs
	1500
	12388
	ENSG00000198561
	ENSMUSG00000034101
	O60716
	P30999
NM_001331; NM_001085458; NM_001085459; NM_001085460; NM_001085461;
	NM_001085462; NM_001085463; NM_001085464; NM_001085465; NM_001085466; NM_001085467; NM_001085468; NM_001085469; NM_001206883; NM_001206884; NM_001206885; NM_001206886; NM_001206887; NM_001206888; NM_001206889; NM_001206890; NM_001206891
NM_001085448; NM_001085449; NM_001085450; NM_001085453; NM_007615;
	NM_001355064; NM_001355065; NM_001355066; NM_001355067
NP_001078927; NP_001078928; NP_001078929; NP_001078930; NP_001078931;
	NP_001078932; NP_001078933; NP_001078934; NP_001078935; NP_001078936; NP_001078937; NP_001078938; NP_001193812; NP_001193813; NP_001193814; NP_001193815; NP_001193816; NP_001193817; NP_001193818; NP_001193819; NP_001193820; NP_001322
NP_001078917; NP_001078918; NP_001078919; NP_001078922; NP_031641;
	NP_001341993; NP_001341994; NP_001341995; NP_001341996
	Wikidata
View/Edit Human	View/Edit Mouse

p120 catenin, or simply p120, also called catenin delta-1, is a protein that in humans is encoded by the CTNND1 gene.^[5]

Function

This gene encodes a member of the Armadillo protein family, which function in adhesion between cells and signal transduction. Multiple translation initiation codons and alternative splicing result in many different isoforms being translated. Not all of the full-length natures of the described transcript variants have been determined.^[6]

Clinical significance

Immunohistochemistry for p120 has cytoplasmic staining in invasive lobular carcinoma (shown), but has membranous staining in invasive ductal carcinoma, thereby helping to distinguish these cancer types.

Either loss or cytoplasmic localization of p120 is a common feature in the progression of several types of carcinoma.^[7]

Interactions

CTNND1 has been shown to interact with:

β-Catenin,^[8]^[9]
CDH1,^[8]^[10]^[11]^[12]^[13]^[14]^[15]^[16]
CDH2,^[17]^[18]
Collagen, type XVII, alpha 1,^[19]
Cortactin,^[20]
FYN,^[10]^[20]
MUC1,^[21]
Nephrin,^[22]
PSEN1,^[23]
PTPN6,^[24]
PTPRJ,^[25]
PTPRM,^[26]
VE-cadherin,^[27]^[28]
YES1,^[10] and
ZBTB33^[29]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000198561 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000034101 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Reynolds AB, Jenkins NA, Gilbert DJ, Copeland NG, Shapiro DN, Wu J, Daniel JM (October 1996). "The gene encoding p120cas, a novel catenin, localizes on human chromosome 11q11 (CTNND) and mouse chromosome 2 (Catns)". Genomics. 31 (1): 127–9. doi:10.1006/geno.1996.0020. PMID 8808291.
^ "Entrez Gene: CTNND1 catenin (cadherin-associated protein), delta 1".
^ Schackmann, R. C. J.; Tenhagen, M.; van de Ven, R. A. H.; Derksen, P. W. B. (2013). "p120-catenin in cancer - mechanisms, models and opportunities for intervention". Journal of Cell Science. 126 (16): 3515–3525. doi:10.1242/jcs.134411. ISSN 0021-9533. PMID 23950111.
^ ^a ^b Hazan RB, Norton L (April 1998). "The epidermal growth factor receptor modulates the interaction of E-cadherin with the actin cytoskeleton". J. Biol. Chem. 273 (15): 9078–84. doi:10.1074/jbc.273.15.9078. PMID 9535896.
^ Kucerová D, Sloncová E, Tuhácková Z, Vojtechová M, Sovová V (December 2001). "Expression and interaction of different catenins in colorectal carcinoma cells". Int. J. Mol. Med. 8 (6): 695–8. doi:10.3892/ijmm.8.6.695. PMID 11712088.
^ ^a ^b ^c Piedra J, Miravet S, Castaño J, Pálmer HG, Heisterkamp N, García de Herreros A, Duñach M (2003). "p120 Catenin-associated Fer and Fyn tyrosine kinases regulate beta-catenin Tyr-142 phosphorylation and beta-catenin-alpha-catenin Interaction". Mol. Cell. Biol. 23 (7): 2287–97. doi:10.1128/MCB.23.7.2287-2297.2003. PMC 150740. PMID 12640114.
^ Daniel JM, Reynolds AB (September 1995). "The tyrosine kinase substrate p120cas binds directly to E-cadherin but not to the adenomatous polyposis coli protein or alpha-catenin". Mol. Cell. Biol. 15 (9): 4819–24. doi:10.1128/mcb.15.9.4819. PMC 230726. PMID 7651399.
^ Ireton RC, Davis MA, van Hengel J, Mariner DJ, Barnes K, Thoreson MA, Anastasiadis PZ, Matrisian L, Bundy LM, Sealy L, Gilbert B, van Roy F, Reynolds AB (2002). "A novel role for p120 catenin in E-cadherin function". J. Cell Biol. 159 (3): 465–76. doi:10.1083/jcb.200205115. PMC 2173073. PMID 12427869.
^ Kinch MS, Clark GJ, Der CJ, Burridge K (1995). "Tyrosine phosphorylation regulates the adhesions of ras-transformed breast epithelia". J. Cell Biol. 130 (2): 461–71. doi:10.1083/jcb.130.2.461. PMC 2199929. PMID 7542250.
^ Bonné S, Gilbert B, Hatzfeld M, Chen X, Green KJ, van Roy F (2003). "Defining desmosomal plakophilin-3 interactions". J. Cell Biol. 161 (2): 403–16. doi:10.1083/jcb.200303036. PMC 2172904. PMID 12707304.
^ Shibamoto S, Hayakawa M, Takeuchi K, Hori T, Miyazawa K, Kitamura N, Johnson KR, Wheelock MJ, Matsuyoshi N, Takeichi M (1995). "Association of p120, a tyrosine kinase substrate, with E-cadherin/catenin complexes". J. Cell Biol. 128 (5): 949–57. doi:10.1083/jcb.128.5.949. PMC 2120395. PMID 7876318.
^ Ohkubo T, Ozawa M (July 1999). "p120(ctn) binds to the membrane-proximal region of the E-cadherin cytoplasmic domain and is involved in modulation of adhesion activity". J. Biol. Chem. 274 (30): 21409–15. doi:10.1074/jbc.274.30.21409. PMID 10409703.
^ Straub BK, Boda J, Kuhn C, Schnoelzer M, Korf U, Kempf T, Spring H, Hatzfeld M, Franke WW (December 2003). "A novel cell-cell junction system: the cortex adhaerens mosaic of lens fiber cells". J. Cell Sci. 116 (Pt 24): 4985–95. doi:10.1242/jcs.00815. PMID 14625392.
^ Wahl JK, Kim YJ, Cullen JM, Johnson KR, Wheelock MJ (May 2003). "N-cadherin-catenin complexes form prior to cleavage of the proregion and transport to the plasma membrane". J. Biol. Chem. 278 (19): 17269–76. doi:10.1074/jbc.M211452200. PMID 12604612.
^ Aho S, Rothenberger K, Uitto J (1999). "Human p120ctn catenin: tissue-specific expression of isoforms and molecular interactions with BP180/type XVII collagen". J. Cell. Biochem. 73 (3): 390–9. doi:10.1002/(SICI)1097-4644(19990601)73:3<390::AID-JCB10>3.0.CO;2-1. PMID 10321838. S2CID 43899550.
^ ^a ^b Martinez MC, Ochiishi T, Majewski M, Kosik KS (2003). "Dual regulation of neuronal morphogenesis by a delta-catenin-cortactin complex and Rho". J. Cell Biol. 162 (1): 99–111. doi:10.1083/jcb.200211025. PMC 2172717. PMID 12835311.
^ Li Y, Kufe D (February 2001). "The Human DF3/MUC1 carcinoma-associated antigen signals nuclear localization of the catenin p120(ctn)". Biochem. Biophys. Res. Commun. 281 (2): 440–3. doi:10.1006/bbrc.2001.4383. PMID 11181067.
^ Lehtonen S, Lehtonen E, Kudlicka K, Holthöfer H, Farquhar MG (2004). "Nephrin forms a complex with adherens junction proteins and CASK in podocytes and in Madin-Darby canine kidney cells expressing nephrin". Am. J. Pathol. 165 (3): 923–36. doi:10.1016/S0002-9440(10)63354-8. PMC 1618613. PMID 15331416.
^ Tanahashi H, Tabira T (February 1999). "Isolation of human delta-catenin and its binding specificity with presenilin 1". NeuroReport. 10 (3): 563–8. doi:10.1097/00001756-199902250-00022. PMID 10208590.
^ Keilhack H, Hellman U, van Hengel J, van Roy F, Godovac-Zimmermann J, Böhmer FD (August 2000). "The protein-tyrosine phosphatase SHP-1 binds to and dephosphorylates p120 catenin". J. Biol. Chem. 275 (34): 26376–84. doi:10.1074/jbc.M001315200. PMID 10835420.
^ Holsinger LJ, Ward K, Duffield B, Zachwieja J, Jallal B (October 2002). "The transmembrane receptor protein tyrosine phosphatase DEP1 interacts with p120(ctn)". Oncogene. 21 (46): 7067–76. doi:10.1038/sj.onc.1205858. PMID 12370829.
^ Zondag GC, Reynolds AB, Moolenaar WH (April 2000). "Receptor protein-tyrosine phosphatase RPTPmu binds to and dephosphorylates the catenin p120(ctn)". J. Biol. Chem. 275 (15): 11264–9. doi:10.1074/jbc.275.15.11264. PMID 10753936.
^ Ferber A, Yaen C, Sarmiento E, Martinez J (March 2002). "An octapeptide in the juxtamembrane domain of VE-cadherin is important for p120ctn binding and cell proliferation". Exp. Cell Res. 274 (1): 35–44. doi:10.1006/excr.2001.5436. PMID 11855855.
^ Lampugnani MG, Corada M, Andriopoulou P, Esser S, Risau W, Dejana E (September 1997). "Cell confluence regulates tyrosine phosphorylation of adherens junction components in endothelial cells". J. Cell Sci. 110 (17): 2065–77. doi:10.1242/jcs.110.17.2065. PMID 9378757.
^ Daniel JM, Reynolds AB (May 1999). "The catenin p120(ctn) interacts with Kaiso, a novel BTB/POZ domain zinc finger transcription factor". Mol. Cell. Biol. 19 (5): 3614–23. doi:10.1128/mcb.19.5.3614. PMC 84161. PMID 10207085.

External links

Human CTNND1 genome location and CTNND1 gene details page in the UCSC Genome Browser.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000198561 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000034101 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8808291-5] Reynolds AB, Jenkins NA, Gilbert DJ, Copeland NG, Shapiro DN, Wu J, Daniel JM (October 1996). "The gene encoding p120cas, a novel catenin, localizes on human chromosome 11q11 (CTNND) and mouse chromosome 2 (Catns)". Genomics. 31 (1): 127–9. doi:10.1006/geno.1996.0020. PMID 8808291.

[6] "Entrez Gene: CTNND1 catenin (cadherin-associated protein), delta 1".

[SchackmannTenhagen2013-7] Schackmann, R. C. J.; Tenhagen, M.; van de Ven, R. A. H.; Derksen, P. W. B. (2013). "p120-catenin in cancer - mechanisms, models and opportunities for intervention". Journal of Cell Science. 126 (16): 3515–3525. doi:10.1242/jcs.134411. ISSN 0021-9533. PMID 23950111.

[pmid9535896-8] Hazan RB, Norton L (April 1998). "The epidermal growth factor receptor modulates the interaction of E-cadherin with the actin cytoskeleton". J. Biol. Chem. 273 (15): 9078–84. doi:10.1074/jbc.273.15.9078. PMID 9535896.

[pmid11712088-9] Kucerová D, Sloncová E, Tuhácková Z, Vojtechová M, Sovová V (December 2001). "Expression and interaction of different catenins in colorectal carcinoma cells". Int. J. Mol. Med. 8 (6): 695–8. doi:10.3892/ijmm.8.6.695. PMID 11712088.

[pmid12640114-10] Piedra J, Miravet S, Castaño J, Pálmer HG, Heisterkamp N, García de Herreros A, Duñach M (2003). "p120 Catenin-associated Fer and Fyn tyrosine kinases regulate beta-catenin Tyr-142 phosphorylation and beta-catenin-alpha-catenin Interaction". Mol. Cell. Biol. 23 (7): 2287–97. doi:10.1128/MCB.23.7.2287-2297.2003. PMC 150740. PMID 12640114.

[pmid7651399-11] Daniel JM, Reynolds AB (September 1995). "The tyrosine kinase substrate p120cas binds directly to E-cadherin but not to the adenomatous polyposis coli protein or alpha-catenin". Mol. Cell. Biol. 15 (9): 4819–24. doi:10.1128/mcb.15.9.4819. PMC 230726. PMID 7651399.

[pmid12427869-12] Ireton RC, Davis MA, van Hengel J, Mariner DJ, Barnes K, Thoreson MA, Anastasiadis PZ, Matrisian L, Bundy LM, Sealy L, Gilbert B, van Roy F, Reynolds AB (2002). "A novel role for p120 catenin in E-cadherin function". J. Cell Biol. 159 (3): 465–76. doi:10.1083/jcb.200205115. PMC 2173073. PMID 12427869.

[pmid7542250-13] Kinch MS, Clark GJ, Der CJ, Burridge K (1995). "Tyrosine phosphorylation regulates the adhesions of ras-transformed breast epithelia". J. Cell Biol. 130 (2): 461–71. doi:10.1083/jcb.130.2.461. PMC 2199929. PMID 7542250.

[pmid12707304-14] Bonné S, Gilbert B, Hatzfeld M, Chen X, Green KJ, van Roy F (2003). "Defining desmosomal plakophilin-3 interactions". J. Cell Biol. 161 (2): 403–16. doi:10.1083/jcb.200303036. PMC 2172904. PMID 12707304.

[pmid7876318-15] Shibamoto S, Hayakawa M, Takeuchi K, Hori T, Miyazawa K, Kitamura N, Johnson KR, Wheelock MJ, Matsuyoshi N, Takeichi M (1995). "Association of p120, a tyrosine kinase substrate, with E-cadherin/catenin complexes". J. Cell Biol. 128 (5): 949–57. doi:10.1083/jcb.128.5.949. PMC 2120395. PMID 7876318.

[pmid10409703-16] Ohkubo T, Ozawa M (July 1999). "p120(ctn) binds to the membrane-proximal region of the E-cadherin cytoplasmic domain and is involved in modulation of adhesion activity". J. Biol. Chem. 274 (30): 21409–15. doi:10.1074/jbc.274.30.21409. PMID 10409703.

[pmid14625392-17] Straub BK, Boda J, Kuhn C, Schnoelzer M, Korf U, Kempf T, Spring H, Hatzfeld M, Franke WW (December 2003). "A novel cell-cell junction system: the cortex adhaerens mosaic of lens fiber cells". J. Cell Sci. 116 (Pt 24): 4985–95. doi:10.1242/jcs.00815. PMID 14625392.

[pmid12604612-18] Wahl JK, Kim YJ, Cullen JM, Johnson KR, Wheelock MJ (May 2003). "N-cadherin-catenin complexes form prior to cleavage of the proregion and transport to the plasma membrane". J. Biol. Chem. 278 (19): 17269–76. doi:10.1074/jbc.M211452200. PMID 12604612.

[pmid10321838-19] Aho S, Rothenberger K, Uitto J (1999). "Human p120ctn catenin: tissue-specific expression of isoforms and molecular interactions with BP180/type XVII collagen". J. Cell. Biochem. 73 (3): 390–9. doi:10.1002/(SICI)1097-4644(19990601)73:3<390::AID-JCB10>3.0.CO;2-1. PMID 10321838. S2CID 43899550.

[pmid12835311-20] Martinez MC, Ochiishi T, Majewski M, Kosik KS (2003). "Dual regulation of neuronal morphogenesis by a delta-catenin-cortactin complex and Rho". J. Cell Biol. 162 (1): 99–111. doi:10.1083/jcb.200211025. PMC 2172717. PMID 12835311.

[pmid11181067-21] Li Y, Kufe D (February 2001). "The Human DF3/MUC1 carcinoma-associated antigen signals nuclear localization of the catenin p120(ctn)". Biochem. Biophys. Res. Commun. 281 (2): 440–3. doi:10.1006/bbrc.2001.4383. PMID 11181067.

[pmid15331416-22] Lehtonen S, Lehtonen E, Kudlicka K, Holthöfer H, Farquhar MG (2004). "Nephrin forms a complex with adherens junction proteins and CASK in podocytes and in Madin-Darby canine kidney cells expressing nephrin". Am. J. Pathol. 165 (3): 923–36. doi:10.1016/S0002-9440(10)63354-8. PMC 1618613. PMID 15331416.

[pmid10208590-23] Tanahashi H, Tabira T (February 1999). "Isolation of human delta-catenin and its binding specificity with presenilin 1". NeuroReport. 10 (3): 563–8. doi:10.1097/00001756-199902250-00022. PMID 10208590.

[pmid10835420-24] Keilhack H, Hellman U, van Hengel J, van Roy F, Godovac-Zimmermann J, Böhmer FD (August 2000). "The protein-tyrosine phosphatase SHP-1 binds to and dephosphorylates p120 catenin". J. Biol. Chem. 275 (34): 26376–84. doi:10.1074/jbc.M001315200. PMID 10835420.

[pmid12370829-25] Holsinger LJ, Ward K, Duffield B, Zachwieja J, Jallal B (October 2002). "The transmembrane receptor protein tyrosine phosphatase DEP1 interacts with p120(ctn)". Oncogene. 21 (46): 7067–76. doi:10.1038/sj.onc.1205858. PMID 12370829.

[pmid10753936-26] Zondag GC, Reynolds AB, Moolenaar WH (April 2000). "Receptor protein-tyrosine phosphatase RPTPmu binds to and dephosphorylates the catenin p120(ctn)". J. Biol. Chem. 275 (15): 11264–9. doi:10.1074/jbc.275.15.11264. PMID 10753936.

[pmid11855855-27] Ferber A, Yaen C, Sarmiento E, Martinez J (March 2002). "An octapeptide in the juxtamembrane domain of VE-cadherin is important for p120ctn binding and cell proliferation". Exp. Cell Res. 274 (1): 35–44. doi:10.1006/excr.2001.5436. PMID 11855855.

[pmid9378757-28] Lampugnani MG, Corada M, Andriopoulou P, Esser S, Risau W, Dejana E (September 1997). "Cell confluence regulates tyrosine phosphorylation of adherens junction components in endothelial cells". J. Cell Sci. 110 (17): 2065–77. doi:10.1242/jcs.110.17.2065. PMID 9378757.

[pmid10207085-29] Daniel JM, Reynolds AB (May 1999). "The catenin p120(ctn) interacts with Kaiso, a novel BTB/POZ domain zinc finger transcription factor". Mol. Cell. Biol. 19 (5): 3614–23. doi:10.1128/mcb.19.5.3614. PMC 84161. PMID 10207085.

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p120 catenin

Contents

Function

Clinical significance

Interactions

See also

References

Further reading

External links