PGC may refer to:
- Pennsylvania Game Commission
- Persian Gulf Cup, Iran's highest association football league
- PGC (gene)
- PGC 1000714, a ring galaxy
- PGC-1α, a protein which is the master regulator of mitochondrial biogenesis
- Playwrights Guild of Canada
- Postgraduate Certificate, usually written as PgC
- Presbyterian Girls' College in Warwick, Australia, now part of Scots PGC College
- Primordial germ cell
- Prince George's County, Maryland
- Principal Galaxies Catalogue
- Principle of Generic Consistency, see Alan Gewirth
- Professional Graphics Controller
- Program chain, which defines the order in which cells, tiles (video, menus, etc.) are played back on a DVD
- Psychiatric Genomics Consortium, founded 2007 as the Psychiatric Genome Wide Association Consortium
- Punjab Group of Colleges, Pakistan
- The University of Pennsylvania Glee Club