TRPP3

Polycystic kidney disease 2-like 2 protein (PKD2L2) also known as transient receptor potential polycystic 5 (TRPP5) is a protein that in humans is encoded by the PKD2L2 gene.

PKD2L2
Identifiers
Aliases	PKD2L2, TRPP5, polycystin 2 like 2, transient receptor potential cation channel
External IDs	OMIM: 604669; MGI: 1858231; HomoloGene: 22812; GeneCards: PKD2L2; OMA:PKD2L2 - orthologs
Gene location (Human) Chr. Chromosome 5 (human) Band 5q31.2 Start 137,887,968 bp End 137,942,747 bp
Gene location (Mouse) Chr. Chromosome 18 (mouse) Band 18|18 B1 Start 34,541,542 bp End 34,577,169 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tendon of biceps brachii buccal mucosa cell testicle left testis right testis sperm internal globus pallidus gonad muscle of thigh Achilles tendon Top expressed in zygote primary oocyte secondary oocyte spermatocyte spermatid granulocyte seminiferous tubule egg cell supraoptic nucleus muscle of thigh More reference expression data BioGPS n/a
Gene ontology Molecular function calcium ion binding calcium channel activity Cellular component integral component of membrane membrane Biological process ion transport detection of mechanical stimulus calcium ion transmembrane transport biological process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 27039 53871 Ensembl ENSG00000078795 ENSMUSG00000014503 UniProt Q9NZM6 Q9JLG4 RefSeq (mRNA) NM_001258448 NM_001258449 NM_001300921 NM_014386 NM_001163004 NM_016927 RefSeq (protein) NP_001245377 NP_001245378 NP_001287850 NP_055201 NP_001156476 NP_058623 Location (UCSC) Chr 5: 137.89 – 137.94 Mb Chr 18: 34.54 – 34.58 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

TRPP5 is a member of the transient receptor potential channel family of proteins.

See also

• TRPP

Further reading

• Li Q, Liu Y, Zhao W, Chen XZ (2002). "The calcium-binding EF-hand in polycystin-L is not a domain for channel activation and ensuing inactivation". FEBS Lett. 516 (1–3): 270–8. Bibcode:2002FEBSL.516..270L. doi:10.1016/S0014-5793(02)02513-9. PMID 11959145. S2CID 1812119.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Stayner C, Zhou J (2001). "Polycystin channels and kidney disease". Trends Pharmacol. Sci. 22 (11): 543–6. doi:10.1016/S0165-6147(00)01832-0. PMID 11698076.
• Guo L, Schreiber TH, Weremowicz S, et al. (2000). "Identification and characterization of a novel polycystin family member, polycystin-L2, in mouse and human: sequence, expression, alternative splicing, and chromosomal localization". Genomics. 64 (3): 241–51. doi:10.1006/geno.2000.6131. PMID 10756092.