Periplakin

Periplakin is a protein that in humans is encoded by the PPL gene.

PPL
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4Q28
Identifiers
Aliases	PPL, periplakin
External IDs	OMIM: 602871; MGI: 1194898; HomoloGene: 2026; GeneCards: PPL; OMA:PPL - orthologs
Gene location (Human) Chr. Chromosome 16 (human) Band 16p13.3 Start 4,882,507 bp End 4,960,741 bp
Gene location (Mouse) Chr. Chromosome 16 (mouse) Band 16 A1|16 2.5 cM Start 4,904,155 bp End 4,950,285 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oral cavity amniotic fluid mucosa of pharynx gums buccal mucosa cell gingival epithelium cervix epithelium skin of arm vulva human penis Top expressed in superior surface of tongue corneal stroma esophagus skin of external ear skin of back lip skin of abdomen epidermis umbilical cord hair follicle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function structural constituent of cytoskeleton protein binding cadherin binding structural molecule activity Cellular component cytoplasm cell junction plasma membrane desmosome extracellular exosome cytoskeleton membrane mitochondrion nucleus cornified envelope cytosol intermediate filament Biological process keratinization cytoskeleton organization cornification response to mechanical stimulus wound healing intermediate filament cytoskeleton organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5493 19041 Ensembl ENSG00000118898 ENSMUSG00000039457 UniProt O60437 Q9R269 RefSeq (mRNA) NM_002705 NM_008909 RefSeq (protein) NP_002696 NP_032935 Location (UCSC) Chr 16: 4.88 – 4.96 Mb Chr 16: 4.9 – 4.95 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene is a component of desmosomes and of the epidermal cornified envelope in keratinocytes. The N-terminal domain of this protein interacts with the plasma membrane and its C-terminus interacts with intermediate filaments. Through its rod domain, this protein forms complexes with envoplakin. This protein may serve as a link between the cornified envelope and desmosomes as well as intermediate filaments. AKT1/PKB, a protein kinase mediating a variety of cell growth and survival signaling processes, is reported to interact with this protein, suggesting a possible role for this protein as a localization signal in AKT1-mediated signaling.

Interactions

PPL (gene) has been shown to interact with Keratin 8 and Envoplakin.

See also

• List of target antigens in pemphigus

Further reading

• Amagai M (1999). "Autoimmunity against desmosomal cadherins in pemphigus". J. Dermatol. Sci. 20 (2): 92–102. doi:10.1016/S0923-1811(99)00016-X. PMID 10379702.
• Leung CL, Green KJ, Liem RK (2002). "Plakins: a family of versatile cytolinker proteins". Trends Cell Biol. 12 (1): 37–45. doi:10.1016/S0962-8924(01)02180-8. PMID 11854008.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Ruhrberg C, Hajibagheri MA, Parry DA, Watt FM (1998). "Periplakin, a novel component of cornified envelopes and desmosomes that belongs to the plakin family and forms complexes with envoplakin". J. Cell Biol. 139 (7): 1835–49. doi:10.1083/jcb.139.7.1835. PMC 2132639. PMID 9412476.
• Nagase T, Ishikawa K, Miyajima N, et al. (1998). "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (1): 31–9. doi:10.1093/dnares/5.1.31. PMID 9628581.
• Aho S, Rothenberger K, Tan EM, et al. (1999). "Human periplakin: genomic organization in a clonally unstable region of chromosome 16p with an abundance of repetitive sequence elements". Genomics. 56 (2): 160–8. doi:10.1006/geno.1998.5704. PMID 10051401.
• DiColandrea T, Karashima T, Määttä A, Watt FM (2000). "Subcellular distribution of envoplakin and periplakin: insights into their role as precursors of the epidermal cornified envelope". J. Cell Biol. 151 (3): 573–86. doi:10.1083/jcb.151.3.573. PMC 2185584. PMID 11062259.
• van den Heuvel AP, de Vries-Smits AM, van Weeren PC, et al. (2003). "Binding of protein kinase B to the plakin family member periplakin". J. Cell Sci. 115 (Pt 20): 3957–66. doi:10.1242/jcs.00069. PMID 12244133. S2CID 12136252.
• Kazerounian S, Uitto J, Aho S (2003). "Unique role for the periplakin tail in intermediate filament association: specific binding to keratin 8 and vimentin". Exp. Dermatol. 11 (5): 428–38. doi:10.1034/j.1600-0625.2002.110506.x. PMID 12366696. S2CID 25735126.
• Karashima T, Watt FM (2003). "Interaction of periplakin and envoplakin with intermediate filaments". J. Cell Sci. 115 (Pt 24): 5027–37. doi:10.1242/jcs.00191. PMID 12432088. S2CID 22383123.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Feng GJ, Kellett E, Scorer CA, et al. (2003). "Selective interactions between helix VIII of the human mu-opioid receptors and the C terminus of periplakin disrupt G protein activation". J. Biol. Chem. 278 (35): 33400–7. doi:10.1074/jbc.M305866200. PMID 12810704.
• Kazerounian S, Aho S (2003). "Characterization of periphilin, a widespread, highly insoluble nuclear protein and potential constituent of the keratinocyte cornified envelope". J. Biol. Chem. 278 (38): 36707–17. doi:10.1074/jbc.M303896200. PMID 12853457.
• Straub BK, Boda J, Kuhn C, et al. (2004). "A novel cell-cell junction system: the cortex adhaerens mosaic of lens fiber cells". J. Cell Sci. 116 (Pt 24): 4985–95. doi:10.1242/jcs.00815. PMID 14625392.
• Kalinin AE, Idler WW, Marekov LN, et al. (2004). "Co-assembly of envoplakin and periplakin into oligomers and Ca(2+)-dependent vesicle binding: implications for cornified cell envelope formation in stratified squamous epithelia". J. Biol. Chem. 279 (21): 22773–80. doi:10.1074/jbc.M313660200. PMID 15033990.
• Beekman JM, Bakema JE, van de Winkel JG, Leusen JH (2004). "Direct interaction between FcgammaRI (CD64) and periplakin controls receptor endocytosis and ligand binding capacity". Proc. Natl. Acad. Sci. U.S.A. 101 (28): 10392–7. Bibcode:2004PNAS..10110392B. doi:10.1073/pnas.0401217101. PMC 478582. PMID 15229321.

External links

• Overview of all the structural information available in the PDB for UniProt: O60437 (Periplakin) at the PDBe-KB.