O-phosphoseryl-tRNASec kinase (EC 2.7.1.164, PSTK, phosphoseryl-tRNA[Ser]Sec kinase, phosphoseryl-tRNASec kinase) is an enzyme with systematic name ATP:L-seryl-tRNASec O-phosphotransferase.[1][2][3] This enzyme catalyses the following chemical reaction
| O-phosphoseryl-tRNASec kinase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.7.1.164 | ||||||||
| CAS no. | 91273-83-5 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
- ATP + L-seryl-tRNASec ADP + O-phospho-L-seryl-tRNASec
In archaea and eukarya selenocysteine formation is achieved by a two-step process.
References
edit- ^ Carlson BA, Xu XM, Kryukov GV, Rao M, Berry MJ, Gladyshev VN, Hatfield DL (August 2004). "Identification and characterization of phosphoseryl-tRNA[Ser]Sec kinase". Proceedings of the National Academy of Sciences of the United States of America. 101 (35): 12848–53. doi:10.1073/pnas.0402636101. PMC 516484. PMID 15317934.
- ^ Sherrer RL, O'Donoghue P, Söll D (March 2008). "Characterization and evolutionary history of an archaeal kinase involved in selenocysteinyl-tRNA formation". Nucleic Acids Research. 36 (4): 1247–59. doi:10.1093/nar/gkm1134. PMC 2275090. PMID 18174226.
- ^ Khangulov SV, Gladyshev VN, Dismukes GC, Stadtman TC (March 1998). "Selenium-containing formate dehydrogenase H from Escherichia coli: a molybdopterin enzyme that catalyzes formate oxidation without oxygen transfer". Biochemistry. 37 (10): 3518–28. doi:10.1021/bi972177k. PMID 9521673.
External links
edit- O-phosphoseryl-tRNASec+kinase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
