Panagiotopoulos or Panayotopoulos (Greek: Παναγιωτόπουλος) is a Greek surname, meaning "son of Panagiotis" and "son of Panagiotou". The feminine form is Panagiotopoulou/Panayotopoulou (Παναγιωτοπούλου) meaning "son of Panagiotopoulos". Notable people with the surname include:
- Diamantis Panagiotopoulos (born 1967), Greek archaeologist
- Georgios Panagiotopoulos (born 1969), Greek sprinter
- Marie Panayotopoulos-Cassiotou (born 1952), Greek politician
- Nicos Panayotopoulos (born 1963), Greek journalist, screenwriter and novelist
- Panos Panagiotopoulos (born 1957), Greek politician
- Georgios Panagiotopoulos (politician) (1930–2021), Greek politician