Pel–Ebstein fever is a rarely seen condition noted in patients with Hodgkin's lymphoma in which the patient experiences fevers which cyclically increase then decrease over an average period of one or two weeks.[2] A cyclic fever may also be associated with other conditions, but it is not called "Pel–Ebstein fever" unless the fever is associated with Hodgkin's.[3]
| Pel–Ebstein fever | |
|---|---|
| Other names | Ebstein–Cardarelli fever[1] |
| Symptoms | fever, enlargement of lymph nodes, night sweats |
Signs and symptoms
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Causes
editThe cause is currently unknown although speculation centers on host immune response – particularly the cyclical release of cytokines, lymph node necrosis, and damaged stromal cells.[4]
Diagnosis
editCyclical fevers normally require periodic temperature monitoring to detect, though it is possible one could sense subjective changes in body temperature as well. To count as Pel-Ebstein fever diagnostic workup for Hodgkin's lymphoma would be required as well if that diagnosis was not already made.[citation needed]
Treatment
editTreatment with non-steroidal anti-inflammatory agents or treatment of the underlying Hodgkin's (usually with chemotherapy) will help the symptoms.[2]
Eponym
editThe condition is named after Wilhelm Ebstein and P. K. Pel who both published papers in 1887 noting the phenomenon.[5][6][7] Both doctors published in the same journal, though Pel published first by several months. A long-term dispute persisted between Pel and Ebstein on the etiology of the condition.[citation needed]
Controversy
editResearchers have speculated whether this condition truly exists, since some authorities anecdotally estimate only a 5–10% occurrence rate.[3] In his Lettsomian Lecture Making Sense, delivered to the Medical Society of London in 1959, Richard Asher refers to Pel–Ebstein fever as an example of a condition that exists only because it has a name. "Every student and every doctor knows that cases of Hodgkin's disease may show a fever that is high for one week and low for the next week and so on. Does this phenomenon really exist at all?..."[8]
References
edit- ^ G. Fradà – Semeiotica Medica nell' adulto e nell'anziano. Piccin p.48
- ^ a b Mauch, Peter; James Armitage; Volker Diehl; Richard Hoppe; Laurence Weiss (1999). Hodgkin's Disease. Lippincott Williams & Wilkins. pp. 327–328. ISBN 978-0-7817-1502-7.
- ^ a b Hochberg, Ephraim P. "eMedicine – Pel–Ebstein Fever". Retrieved 2007-07-08.
- ^ Ree, HJ (1987). "Stromal macrophage-histiocytes in Hodgkin's disease. Their relation to fever". Cancer. 60 (1479): 1479–84. doi:10.1002/1097-0142(19871001)60:7<1479::AID-CNCR2820600713>3.0.CO;2-G. PMID 3621125.
- ^ Ebstein, Wilhelm (1887). "Das chronische Ruckfallsfieber, eine neue Infectionskrankheit". Berlin Klin Wochenschr. 24 (565).
- ^ Pel, P. K. (1887). "Pseudoleukaemie oder chronisches Ruckfallsfieber?". Berlin Klin Wochenschr. 24 (565).
- ^ synd/438 at Who Named It?
- ^ Hilson, A.J.W.; DiNubile, M.J. (1995-07-06). "Correspondence". New England Journal of Medicine. 333 (1): 66–67. doi:10.1056/NEJM199507063330118. PMID 7777006.. They cite Richard Asher's lecture Making Sense (Lancet, 1959, 2, 359)