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Peter Kohl (physiologist)

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Peter Kohl is a German scientist specializing in integrative cardiac research. He studies heterocellular electrophysiological interactions in cardiac tissue,[1][2][3] myocardial structure-function relationships using 'wet' and 'dry' lab models,[4][5][6] and mechano-electrical autoregulation of the heart.[7][8][9]

Peter Kohl
Born1962 (age 61–62)
Berlin, East Germany
NationalityGerman, British
AwardsFellow of the International Union of Physiological Sciences 2023

Fellow of The Physiological Society 2017
Fellow of the American Heart Association 2014

Fellow of the Heart Rhythm Society 2011
Scientific career
InstitutionsUniversity of Freiburg

Imperial College London
University of Oxford

Charité, Humboldt University of Berlin
Website

Education

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Kohl studied medicine and biophysics in Moscow before completing his doctorate and his residency in physiology at the Humboldt University in Berlin. Supported by a scholarship from the Boehringer-Ingelheim Foundation, he went as a post-doctoral researcher to the chair of Prof. Denis Noble, Department of Physiology at the University of Oxford, where - using a combination of experimental and theoretical models - he explored cardiac mechanobiology and heterocellular interactions.[1][8][10]

Career

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Supported by personal fellowships from the UK Royal Society and the British Heart Foundation, he founded the Cardiac Mechano-Electric Feedback Lab at Oxford. Work from this time ranged from the mechanistic explanation of the Bainbridge effect (mechanically induced increase in heart rate) in isolated pacemaker cells stretched during patch clamp measurements with carbon fibres,[11] the description of a stretch-induced increase in calcium release from the sarcoplasmic reticulum as a mechanism contributing to the Frank–Starling law,[12] to the exploration of direct electrical coupling of cardiac fibroblasts and muscle cells.[1][2][13]

After two decades of research and teaching at Oxford, Kohl was appointed Inaugural Chair in Cardiac Biophysics and Systems Biology at Imperial College London. Work during this time, funded by the ERC Advanced Grant CardioNECT, focused on the development and use of novel optogenetic and fluorometric techniques,[14] resulting in the first functional demonstration of heterocellular electrical cell coupling in native heart tissue.[3] After five years in London, Kohl was recruited to Freiburg University in 2016 as the founding director of the Institute for Experimental Cardiovascular Medicine (IEKM).[15][16]

The English-language IEKM is structured with flat hierarchies and a broad interdisciplinary profile.[17] About 40% of staff are from outside Germany, with scientific backgrounds in physiology, pharmacology, medicine, biology, physics, engineering and mathematics. The institute has grown from 6 to almost 60 staff and students in just a few years, established a novel biobank concept (in which functional data collected on live human tissue are an integral part of the biobank), and it is committed to teaching in small group formats such as the new 1-year international MSc in Medical Sciences - Cardiovascular Research with an annual intake of no more than 6 pre-PhD students.

Honours

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Kohl is a visiting professor at the University of Oxford[18] and Imperial College London.[19][20] He served as co-founding director (with Peter Coveney, University College London) of the Virtual Physiological Human Network of Excellence (VPH NoE)[21] and he is the Speaker of the German national collaborative research centre SFB1425 'Make Better Scars'.[22] From 2018-2020, Kohl was joint Editor-in-Chief (with Denis Noble and Tom Blundell) of Progress in Biophysics and Molecular Biology, and from 2022-2023, he was Editor-in-Chief of The Journal of Physiology.[23]

References

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  1. ^ a b c Camelliti, P; Green, CR; LeGrice, I; Kohl, P (2004). "Fibroblast network in rabbit sinoatrial node: structural and functional identification of homogeneous and heterogeneous cell coupling". Circulation Research. 94 (6): 828–835. doi:10.1161/01.RES.0000122382.19400.14. ISSN 1524-4571. PMID 14976125. S2CID 16474087.
  2. ^ a b Gourdie, R.G.; Dimmeler, S; Kohl, P (2016). "Novel therapeutic strategies targeting fibroblasts and fibrosis in heart disease". Nature Reviews. Drug Discovery. 15 (9): 620–638. doi:10.1038/nrd.2016.89. ISSN 1474-1784. PMC 5152911. PMID 27339799.
  3. ^ a b Quinn, T.A.; Camelliti, P; Rog-Zielinska, EA; Siedlecka, U; Poggioli, T; O'Toole, ET; Knöpfel, T; Kohl, P (2016). "Electrotonic coupling of excitable and nonexcitable cells in the heart revealed by optogenetics". Proceedings of the National Academy of Sciences of the United States of America. 113 (51): 14852–14857. Bibcode:2016PNAS..11314852Q. doi:10.1073/pnas.1611184114. ISSN 1091-6490. PMC 5187735. PMID 27930302.
  4. ^ Kohl, P; Crampin, EJ; Quinn, TA; Noble, D (2010). "Systems biology: an approach". Clinical Pharmacology and Therapeutics. 88 (1): 25–33. doi:10.1038/clpt.2010.92. ISSN 1532-6535. PMID 20531468. S2CID 40907184.
  5. ^ Quinn, TA; Kohl, P (2013). "Combining wet and dry research: experience with model development for cardiac mechano-electric structure-function studies". Cardiovascular Research. 97 (4): 601–611. doi:10.1093/cvr/cvt003. ISSN 1755-3245. PMC 3583260. PMID 23334215.
  6. ^ Iribe, G; Kohl, P (2008). "Axial stretch enhances sarcoplasmic reticulum Ca2+ leak and cellular Ca2+ reuptake in guinea pig ventricular myocytes: experiments and models". Progress in Biophysics and Molecular Biology. 97 (2–3): 298–311. doi:10.1016/j.pbiomolbio.2008.02.012. ISSN 0079-6107. PMID 18395247.
  7. ^ Peyronnet, R; Nerbonne, JM; Kohl, P (2016). "Cardiac Mechano-Gated Ion Channels and Arrhythmias". Circulation Research. 118 (2): 311–329. doi:10.1161/CIRCRESAHA.115.305043. ISSN 1524-4571. PMC 4742365. PMID 26838316.
  8. ^ a b Kohl, P; Hunter, P; Noble, D (1999). "Stretch-induced changes in heart rate and rhythm: clinical observations, experiments and mathematical models". Progress in Biophysics and Molecular Biology. 71 (1): 91–138. doi:10.1016/s0079-6107(98)00038-8. ISSN 0079-6107. PMID 10070213.
  9. ^ Quinn, TA; Kohl, P (2021). "Cardiac Mechano-Electric Coupling: Acute Effects of Mechanical Stimulation on Heart Rate and Rhythm". Physiological Reviews. 101 (1): 37–92. doi:10.1152/physrev.00036.2019. ISSN 1522-1210. PMID 32380895. S2CID 218554597.
  10. ^ Kohl, P; Day, K; Noble, D (1998). "Cellular mechanisms of cardiac mechano-electric feedback in a mathematical model". The Canadian Journal of Cardiology. 14 (1): 111–119. ISSN 0828-282X. PMID 9487283.
  11. ^ Cooper, PJ; Lei, M; Cheng, LX; Kohl, P (2000). "Selected contribution: axial stretch increases spontaneous pacemaker activity in rabbit isolated sinoatrial node cells". Journal of Applied Physiology. 89 (5): 2099–2104. doi:10.1152/jappl.2000.89.5.2099. ISSN 8750-7587. PMID 11053369. S2CID 9211863.
  12. ^ Iribe, G; Ward, CW; Camelliti, P; Bollensdorff, C; Mason, F; Burton, RAB; Garny, A; Morphew, MK; Hoenger, A; Lederer, WJ; Kohl, P (2009-03-27). "Axial stretch of rat single ventricular cardiomyocytes causes an acute and transient increase in Ca2+ spark rate". Circulation Research. 104 (6): 787–795. doi:10.1161/CIRCRESAHA.108.193334. ISSN 1524-4571. PMC 3522525. PMID 19197074.
  13. ^ Kohl, P; Kamkin, AG; Kiseleva, I S.; Noble, D (1994). "Mechanosensitive fibroblasts in the sino-atrial node region of rat heart: interaction with cardiomyocytes and possible role". Experimental Physiology. 79 (6): 943–956. doi:10.1113/expphysiol.1994.sp003819. ISSN 0958-0670. PMID 7873162. S2CID 36074805.
  14. ^ Yan, P; Acker, CD; Zhou, W-L; Lee, P; Bollensdorff, C; Negrean, A; Lotti, J; Sacconi, L; Antic, SD; Kohl, P; Mansvelder, HD (2012). "Palette of fluorinated voltage-sensitive hemicyanine dyes". Proceedings of the National Academy of Sciences of the United States of America. 109 (50): 20443–20448. Bibcode:2012PNAS..10920443Y. doi:10.1073/pnas.1214850109. ISSN 1091-6490. PMC 3528613. PMID 23169660.
  15. ^ "Experimental Cardiovascular Medicine | Universitätsklinikum Freiburg". www.uniklinik-freiburg.de.
  16. ^ "Prof Peter Kohl at Freiburg University". www.med.uni-freiburg.de.
  17. ^ Verheyen, J; Kohl, P; Peyronnet, R (2019). "The Institute for Experimental Cardiovascular Medicine in Freiburg". Biophysical Reviews. 11 (5): 675–677. doi:10.1007/s12551-019-00593-4. ISSN 1867-2450. PMC 6815290. PMID 31529359.
  18. ^ "Prof Peter Kohl at the University of Oxford". www.dpag.ox.ac.uk.
  19. ^ "Prof Peter Kohl at Imperial College". www.imperial.ac.uk.
  20. ^ "Inaugural lecture of Prof Peter Kohl at Imperial College". YouTube.
  21. ^ "European Network of Excellence 'Virtual Physiological Human'". cordis.europa.eu/project/id/223920.
  22. ^ "SFB 1425". www.sfb1425.uni-freiburg.de.
  23. ^ Wylde, Emily. "The Society welcomes new Editor-in-Chief of The Journal of Physiology".
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