PGI may refer to:
- Parking guidance and information, signs and other indicators to assist in parking a car
- Performance Grading Index - An annual report for quality of school education in India.
- PGI (The Portland Group, Inc.), a former software company providing compilers and programming tools, now part of Nvidia
- PGI Management, currently known as Pas Grau International an Andorra-based ski operation management company
- PGI, IATA code for Chitato Airport in Angola
- PGI2 (Prostacyclin), a chemical which regulates blood clotting
- Phosphoglucose isomerase, alternate name for Glucose-6-phosphate isomerase
- Piranha Games Inc., a Canadian video game developer
- Pontefract General Infirmary, the former name for Pontefract Hospital
- Postgraduate Institute of Medical Education and Research, a medical institute and research centre in Chandigarh, India
- Project for Good Information, American political group
- Protected geographical indication, one of the three protected denominations for agricultural products of the European Union
- Pyrotechnics Guild International, association of professional and amateur fireworks enthusiasts