Po2, pO2, PO2, or PO2 may refer to:
- A military rank:
- Petty Officer 2nd Class in the Canadian military
- Petty Officer Second Class in the United States military
- Polikarpov Po-2 or U-2, a Soviet aeroplane
- Partial pressure of Oxygen, that is, amount of oxygen in the blood (normally referred to as Dissolved Oxygen)
- PO2: Phosphorus dioxide, a gaseous free radical that plays a role in the chemiluminescence of phosphorus and phosphine.
- Po2−: Polonide anion
- a power of two in mathematics
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