Family Guy creator Seth MacFarlane also provides the voices of Peter Griffin, Stewie Griffin, Brian Griffin, and Glenn Quagmire.

The cast members of Family Guy, an American animated sitcom that features five main voice actors, and numerous regular cast and recurring guest stars. The principal voice cast consists of show creator Seth MacFarlane (pictured), Alex Borstein, Seth Green, Mila Kunis (who replaced Lacey Chabert after the first season) and Mike Henry. Recurring voice actors include Patrick Warburton, Adam West, John G. Brennan, Nicole Sullivan and Jennifer Tilly, and repeat guest stars include Phyllis Diller, Charles Durning, Rush Limbaugh, and Phil LaMarr. Many cast members provide voices for multiple characters. The voice actors, in portraying the various character personalities on the show, draw inspiration from celebrities and pop culture. Family Guy characters have been played by more than one actor, after members of the show left the series or had conflicting obligations. Kunis was nominated for an Annie Award for voicing Meg Griffin in the season 5 episode "Barely Legal" and MacFarlane has also won an Emmy Award for Outstanding Voice-Over Performance and an Annie Award for Best Voice Acting in an Animated Television Production, though no other cast member has won an award for their work on the series.