- 2 November 1917 – The Hooker Telescope at Mount Wilson Observatory, the largest telescope in the world from 1917 until 1948, sees first light
- 14 November 1971 – Unmanned probe Mariner 9 arrives at Mars and becomes the first spacecraft to orbit around another planet
- 18 November 1989 – Explorer 66, a satellite designed to study cosmic microwave background radiation and supply evidence in support of the Big Bang theory, is launched
- 20 November 1998 – Zarya, the first module of the International Space Station, is launched
- 28 November 1967 – PSR B1919+21 becomes the first pulsar to be observed when it is discovered by Jocelyn Bell Burnell and Antony Hewish
