William Henry Sheppard (1865–1927) was one of the earliest African Americans to become a missionary for the Presbyterian Church. He spent 20 years in Africa, primarily in and around the Congo Free State, and is best known for his efforts to publicize the atrocities committed against the Kuba and other Congolese peoples by King Leopold II's Force Publique.

Sheppard's efforts contributed to the contemporary debate on European colonialism and imperialism in the region, particularly amongst those of the African American community. However, it has been noted that he traditionally received little attention in literature on the subject.