- April 30: Mayor Michael Nutter signs a law banning talking on a hand-held cell phone while driving in Philadelphia. (KYW)
- April 29: A judge dismisses a Chapter 11 bankruptcy petition from Old Original Bookbinder's, making it unlikely the restaurant will reopen. (Philadelphia Inquirer)
- April 28: Senator Arlen Spector announces that he has switched political parties from Republican to Democrat. (CNN)
- April 22: Liberty Property Trust announces the Comcast Center received a gold LEED rating. (Philadelphia business Journal)
- April 13: Philadelphia Phillies broadcaster Harry Kalas dies. (Philadelphia Inquirer)
- April 6: The U.S. Supreme Court rejects a bid for a new trial for Mumia Abu-Jamal. (CNN)
- April 5: Drexel University president Constantine Papadakis dies. (Philadelphia Inquirer)
