- September 25: A public smoking ban goes into effect for Philadelphia bars and restaurants. (WPVI-TV)
- September 22: Eight days after signing a smoking ban law, Mayor Street announces that the ban will go into effect as early as September 25. (Philadelphia Inquirer)
- September 21: The Philadelphia Orchestra announces that it will be the first major U.S. orchestra to sell downloads of its performances directly from the orchestra's website. (Fox News)
- September 14: Mayor Street signs a smoking ban law that will go effect in 2007. (WPVI-TV)
- September 12: Amtrak announces plans for high-speed train service between Philadelphia and Harrisburg along the Keystone Corridor. (Philadelphia Inquirer)
- September 9: Space Shuttle Atlantis lifts off from the Kennedy Space Center with Philadelphia native, Christopher Ferguson as the shuttle's pilot. (CNN)
- September 6: The Philadelphia Art Commission approves the placement of a statue of Sylvester Stallone's film character, Rocky Balboa, from the film Rocky III near the steps of the Philadelphia Museum of Art. (WCAU)
- September 5: The Archdiocese of Philadelphia and the union that represents Roman Catholic high schools' teachers in Philadelphia and its suburbs agree to a new contract avoiding a strike. (KYW-TV)
- September 2: The remnants of Hurricane Ernesto cause power outages in parts of southeastern Pennsylvania. (Philadelphia Inquirer)
