May 3, 1502 – In present-day Venezuela, the Spanish conquistadors led by Alonso de Ojeda founded the village of Santa Cruz de Coquibacoa, the first European settlement in the Americas.
May 6, 1873 – Death of José Antonio Páez, politician and independence leader, three-time President of Venezuela (b. 1790)
May 13, 1958 – During a visit to Caracas, Venezuela, US Vice President Richard Nixon's car is attacked by anti-American demonstrators.
May 14, 1777 – In Madrid, Carlos III created the Protomedicato de Caracas by royal decree, thus beginning medical studies in Venezuela.
May 18, 1499 – Alonso de Ojeda sets sail from Cádiz on his voyage to what is now Venezuela.
May 21, 2014 – Death of Jaime Lusinchi, physician and politician, President of Venezuela (b. 1924)
May 24, 1813 – South American independence leader Simón Bolívar enters Mérida, leading the invasion of Venezuela, and is proclaimed El Libertador ("The Liberator").
May 27, 1924 – Birth of Jaime Lusinchi, physician and politician, President of Venezuela (d. 2014)
May 27, 2007 – Hugo Chávez controversially closes the private television station Radio Caracas Television (RCTV); the next day he replaces it with a state-run television service.