Poulos is the Greek-origin surname for:

It can also refer to:

  • Alex Poulos, a fictional character from the Australian soap opera Home and Away
  • Leah Poulos, birth name of Leah Patterson-Baker, another fictional character of the Australian soap opera Home and Away
  • Poulos v. New Hampshire, a 1953 case of the Supreme Court of the United States
  • -poulos, a common surname suffix found in some Greek families