Powel is a surname and given name. Notable people with the name include:
- David Powel (c.1549–1598), Welsh clergyman and historian
- Samuel Powel (1738–1793), American colonial politician
- William Garrigues Powel (1852–1894), American politician
- Powel Crosley Jr. (1886–1961), American industrialist
- Powel J. Smith (1874–1942), American businessman and politician