In enzymology, a progesterone 11alpha-monooxygenase (EC 1.14.99.14) is an enzyme that catalyzes the chemical reaction
| progesterone 11-alpha-monooxygenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.14.99.14 | ||||||||
| CAS no. | 37256-77-2 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
- progesterone + AH2 + O2 11alpha-hydroxyprogesterone + A + H2O
The 3 substrates of this enzyme are progesterone, AH2, and O2, whereas its 3 products are 11alpha-hydroxyprogesterone, A, and H2O.
This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derive from O miscellaneous. The systematic name of this enzyme class is progesterone,hydrogen-donor:oxygen oxidoreductase (11alpha-hydroxylating). This enzyme is also called progesterone 11alpha-hydroxylase. This enzyme participates in c21-steroid hormone metabolism.
References
edit- Shibahara M, Moody JA, Smith LL (1970). "Microbial hydroxylations. V. 11-alpha-hydroxylation of progesterone by cell-free preparations of Aspergillus ochraceus". Biochim. Biophys. Acta. 202 (1): 172–9. doi:10.1016/0005-2760(70)90228-6. PMID 5417182.
