Prostaglandin E synthase

prostaglandin E synthase (microsomal)
prostaglandin E synthase (microsomal)
Identifiers
Symbol	PTGES
Alt. symbols	MGST1L1
NCBI gene	9536
HGNC	9599
OMIM	605172
RefSeq	NM_004878
UniProt	O14684
Other data
Locus	Chr. 9 q34.3
Structures
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Structures	Swiss-model
Domains	InterPro

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PMC	articles
PubMed	articles
NCBI	proteins

prostaglandin-E synthase
prostaglandin-E synthase
	human microsomal prostaglandin E synthase 1 with bound glutathione. PDB entry 3DWW
Identifiers
EC no.	5.3.99.3
CAS no.	52227-79-9
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
PMC
Search
PMC	articles
PubMed	articles
NCBI	proteins

Prostaglandin E synthase (EC 5.3.99.3, or PGE synthase) is an enzyme involved in eicosanoid and glutathione metabolism, a member of MAPEG family. It generates prostaglandin E (PGE) from prostaglandin H2.^[2]^[3]

The synthase generating PGE2 is a membrane-associated protein.

Isozymes

Humans express three prostaglandin-E synthase isozymes, each encoded by a separate gene:

prostaglandin E synthase 2 (microsomal)

Identifiers

Symbol

PTGES2

Alt. symbols

C9orf15

Other data

Chr. 9 q34.12

Search for
Structures	Swiss-model
Domains	InterPro

prostaglandin E synthase 3 (cytosolic)

Identifiers

Symbol

PTGES3

Alt. symbols

p23, TEBP, cPGES

Other data

Chr. 12 q13.13

Search for
Structures	Swiss-model
Domains	InterPro

References

^ Jegerschold, C.; Pawelzik, S. -C.; Purhonen, P.; Bhakat, P.; Gheorghe, K. R.; Gyobu, N.; Mitsuoka, K.; Morgenstern, R.; Jakobsson, P. -J.; Hebert, H. (2008). "Structural basis for induced formation of the inflammatory mediator prostaglandin E2". Proceedings of the National Academy of Sciences. 105 (32): 11110–11115. Bibcode:2008PNAS..10511110J. doi:10.1073/pnas.0802894105. PMC 2516235. PMID 18682561.
^ Murakami M, Nakatani Y, Tanioka T, Kudo I (August 2002). "Prostaglandin E synthase". Prostaglandins Other Lipid Mediat. 68–69: 383–99. doi:10.1016/S0090-6980(02)00043-6. PMID 12432931. S2CID 22246484.
^ Park JY, Pillinger MH, Abramson SB (June 2006). "Prostaglandin E2 synthesis and secretion: the role of PGE2 synthases". Clin. Immunol. 119 (3): 229–40. doi:10.1016/j.clim.2006.01.016. PMID 16540375.

External links

prostaglandin-E+synthase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
EC 5.3.99.3

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[1] Jegerschold, C.; Pawelzik, S. -C.; Purhonen, P.; Bhakat, P.; Gheorghe, K. R.; Gyobu, N.; Mitsuoka, K.; Morgenstern, R.; Jakobsson, P. -J.; Hebert, H. (2008). "Structural basis for induced formation of the inflammatory mediator prostaglandin E2". Proceedings of the National Academy of Sciences. 105 (32): 11110–11115. Bibcode:2008PNAS..10511110J. doi:10.1073/pnas.0802894105. PMC 2516235. PMID 18682561.

[pmid12432931-2] Murakami M, Nakatani Y, Tanioka T, Kudo I (August 2002). "Prostaglandin E synthase". Prostaglandins Other Lipid Mediat. 68–69: 383–99. doi:10.1016/S0090-6980(02)00043-6. PMID 12432931. S2CID 22246484.

[pmid16540375-3] Park JY, Pillinger MH, Abramson SB (June 2006). "Prostaglandin E2 synthesis and secretion: the role of PGE2 synthases". Clin. Immunol. 119 (3): 229–40. doi:10.1016/j.clim.2006.01.016. PMID 16540375.

[2]

[3]

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