Pyroglutamylated RFamide peptide receptor also known as orexigenic neuropeptide QRFP receptor or G-protein coupled receptor 103 (GPR103) is a protein that in humans is encoded by the QRFPR gene .[ 5] [ 6]
G protein-coupled receptors (GPCRs, or GPRs) contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins .[ 5]
A 26-amino acid RF-amide peptide, P518 functions as a high-affinity ligand of GPR103. Both GPR103 and P518 precursor mRNA exhibited highest expression in brain.[ 7] QRFP peptide, a longer form of the P518 peptide is necessary to exhibit full agonistic activity with GPR103. Intravenous administration QRFP caused release of aldosterone , suggesting that QRFP and GPR103 regulate adrenal function.[ 8]
^ a b c GRCh38: Ensembl release 89: ENSG00000186867 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000058400 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ a b "Entrez Gene: GPR103 G protein-coupled receptor 103" .^ Lee DK, Nguyen T, Lynch KR, Cheng R, Vanti WB, Arkhitko O, Lewis T, Evans JF, George SR, O'Dowd BF (September 2001). "Discovery and mapping of ten novel G protein-coupled receptor genes". Gene . 275 (1): 83–91. doi :10.1016/S0378-1119(01)00651-5 . PMID 11574155 . ^ Jiang Y, Luo L, Gustafson EL, Yadav D, Laverty M, Murgolo N, Vassileva G, Zeng M, Laz TM, Behan J, Qiu P, Wang L, Wang S, Bayne M, Greene J, Monsma F, Zhang FL (July 2003). "Identification and characterization of a novel RF-amide peptide ligand for orphan G-protein-coupled receptor SP9155" . J. Biol. Chem . 278 (30): 27652–7. doi :10.1074/jbc.M302945200 PMID 12714592 . ^ Fukusumi S, Yoshida H, Fujii R, Maruyama M, Komatsu H, Habata Y, Shintani Y, Hinuma S, Fujino M (November 2003). "A new peptidic ligand and its receptor regulating adrenal function in rats" . J. Biol. Chem . 278 (47): 46387–95. doi :10.1074/jbc.M305270200 PMID 12960173 .
Lee DK, Nguyen T, Lynch KR, et al. (2001). "Discovery and mapping of ten novel G protein-coupled receptor genes". Gene . 275 (1): 83–91. doi :10.1016/S0378-1119(01)00651-5 . PMID 11574155 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Jiang Y, Luo L, Gustafson EL, et al. (2003). "Identification and characterization of a novel RF-amide peptide ligand for orphan G-protein-coupled receptor SP9155" . J. Biol. Chem . 278 (30): 27652–7. doi :10.1074/jbc.M302945200 PMID 12714592 . Fukusumi S, Yoshida H, Fujii R, et al. (2004). "A new peptidic ligand and its receptor regulating adrenal function in rats" . J. Biol. Chem . 278 (47): 46387–95. doi :10.1074/jbc.M305270200 PMID 12960173 . Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes" . Genome Res . 16 (1): 55–65. doi :10.1101/gr.4039406 . PMC 1356129 PMID 16344560 . Takayasu S, Sakurai T, Iwasaki S, et al. (2006). "A neuropeptide ligand of the G protein-coupled receptor GPR103 regulates feeding, behavioral arousal, and blood pressure in mice" . Proc. Natl. Acad. Sci. U.S.A . 103 (19): 7438–43. Bibcode :2006PNAS..103.7438T . doi :10.1073/pnas.0602371103 PMC 1464357 PMID 16648250 .
