Qo or QO may refer to:
- Aeromexpress (IATA airline designator QO)
- Origin Pacific Airways (IATA airline designator QO)
- QO, a line of electrical circuit breakers made by Square D
- Qoheleth, aka Ecclesiastes, a book of the Hebrew Bible
- quaestiō, Latin for "question", a possible origin of the question mark
- Quickoffice, a software package
QO
, the region subtag used in the Unicode Common Locale Data Repository for Outlying Oceania