RhoD (Ras homolog gene family, member D) is a small (~21 kDa) signaling G protein (more specifically a GTPase), and is a member of the Rac subfamily of the family Rho family of GTPases.[5] It is encoded by the gene RHOD.[6]
It binds GTP and is involved in endosome dynamics and reorganization of the actin cytoskeleton, and it may coordinate membrane transport with the function of the cytoskeleton.[6][7]
Interactions
editRhoD has been shown to interact with CNKSR1[8] and DIAPH2.[9]
References
edit- ^ a b c GRCh38: Ensembl release 89: ENSG00000173156 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000041845 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Ridley AJ (October 2006). "Rho GTPases and actin dynamics in membrane protrusions and vesicle trafficking". Trends in Cell Biology. 16 (10): 522–529. doi:10.1016/j.tcb.2006.08.006. PMID 16949823.
- ^ a b "Entrez Gene: RHOD ras homolog gene family, member D".
- ^ Nehru V, Voytyuk O, Lennartsson J, Aspenström P (December 2013). "RhoD binds the Rab5 effector Rabankyrin-5 and has a role in trafficking of the platelet-derived growth factor receptor". Traffic. 14 (12): 1242–1254. doi:10.1111/tra.12121. PMID 24102721. S2CID 3416403.
- ^ Jaffe AB, Aspenström P, Hall A (February 2004). "Human CNK1 acts as a scaffold protein, linking Rho and Ras signal transduction pathways". Molecular and Cellular Biology. 24 (4): 1736–1746. doi:10.1128/MCB.24.4.1736-1746.2004. PMC 344169. PMID 14749388.
- ^ Gasman S, Kalaidzidis Y, Zerial M (March 2003). "RhoD regulates endosome dynamics through Diaphanous-related Formin and Src tyrosine kinase". Nature Cell Biology. 5 (3): 195–204. doi:10.1038/ncb935. PMID 12577064. S2CID 17891748.
Further reading
edit- Ridley AJ (May 2001). "Rho proteins: linking signaling with membrane trafficking". Traffic. 2 (5): 303–310. doi:10.1034/j.1600-0854.2001.002005303.x. PMID 11350626. S2CID 37763952.
- Shimizu F, Watanabe TK, Okuno S, Omori Y, Fujiwara T, Takahashi E, Nakamura Y (March 1997). "Isolation of a novel human cDNA (rhoHP1) homologous to rho genes". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1351 (1–2): 13–16. doi:10.1016/s0167-4781(97)00008-0. PMID 9116026.
- Kim HS, Choi JY, Jung AR, Jang KL, Lee WH, Choi WC, et al. (2000). "Assignment of the human RhoHP1 gene (ARHD) to chromosome 11q14.3 by radiation hybrid mapping". Cytogenetics and Cell Genetics. 89 (1–2): 53. doi:10.1159/000015562. PMID 10894936. S2CID 84584317.
- Murphy C, Saffrich R, Olivo-Marin JC, Giner A, Ansorge W, Fotsis T, Zerial M (June 2001). "Dual function of rhoD in vesicular movement and cell motility". European Journal of Cell Biology. 80 (6): 391–398. doi:10.1078/0171-9335-00173. PMID 11484930.
- Zanata SM, Hovatta I, Rohm B, Püschel AW (January 2002). "Antagonistic effects of Rnd1 and RhoD GTPases regulate receptor activity in Semaphorin 3A-induced cytoskeletal collapse". The Journal of Neuroscience. 22 (2): 471–477. doi:10.1523/JNEUROSCI.22-02-00471.2002. PMC 6758682. PMID 11784792.
- Gasman S, Kalaidzidis Y, Zerial M (March 2003). "RhoD regulates endosome dynamics through Diaphanous-related Formin and Src tyrosine kinase". Nature Cell Biology. 5 (3): 195–204. doi:10.1038/ncb935. PMID 12577064. S2CID 17891748.
- Jaffe AB, Aspenström P, Hall A (February 2004). "Human CNK1 acts as a scaffold protein, linking Rho and Ras signal transduction pathways". Molecular and Cellular Biology. 24 (4): 1736–1746. doi:10.1128/MCB.24.4.1736-1746.2004. PMC 344169. PMID 14749388.
- Flaxenburg JA, Melter M, Lapchak PH, Briscoe DM, Pal S (June 2004). "The CD40-induced signaling pathway in endothelial cells resulting in the overexpression of vascular endothelial growth factor involves Ras and phosphatidylinositol 3-kinase". Journal of Immunology. 172 (12): 7503–7509. doi:10.4049/jimmunol.172.12.7503. PMID 15187129.
- Barrios-Rodiles M, Brown KR, Ozdamar B, Bose R, Liu Z, Donovan RS, et al. (March 2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–1625. Bibcode:2005Sci...307.1621B. doi:10.1126/science.1105776. PMID 15761153. S2CID 39457788.
- Birukova AA, Chatchavalvanich S, Rios A, Kawkitinarong K, Garcia JG, Birukov KG (May 2006). "Differential regulation of pulmonary endothelial monolayer integrity by varying degrees of cyclic stretch". The American Journal of Pathology. 168 (5): 1749–1761. doi:10.2353/ajpath.2006.050431. PMC 1606576. PMID 16651639.
- Ito Y, Kanamaru A, Tada A (March 2007). "A novel agent, methylophiopogonanone B, promotes Rho activation and tubulin depolymerization". Molecular and Cellular Biochemistry. 297 (1–2): 121–129. doi:10.1007/s11010-006-9336-y. PMID 17029007. S2CID 33688226.
- Tan W, Martin D, Gutkind JS (December 2006). "The Galpha13-Rho signaling axis is required for SDF-1-induced migration through CXCR4". The Journal of Biological Chemistry. 281 (51): 39542–39549. doi:10.1074/jbc.M609062200. PMID 17056591.
- Lakshman N, Kim A, Bayless KJ, Davis GE, Petroll WM (June 2007). "Rho plays a central role in regulating local cell-matrix mechanical interactions in 3D culture". Cell Motility and the Cytoskeleton. 64 (6): 434–445. doi:10.1002/cm.20194. PMID 17342762.
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