Rnd1 is a small (~21 kDa) signaling G protein (to be specific, a GTPase ), and is a member of the Rnd subgroup of the Rho family of GTPases .[ 5] RND1 .[ 6]
It contributes to regulating the organization of the actin cytoskeleton in response to extracellular growth factors (Nobes et al., 1998).[supplied by OMIM][ 6]
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Nobes CD, Lauritzen I, Mattei MG, Paris S, Hall A, Chardin P (Apr 1998). "A new member of the Rho family, Rnd1, promotes disassembly of actin filament structures and loss of cell adhesion" . The Journal of Cell Biology . 141 (1): 187–97. doi :10.1083/jcb.141.1.187 . PMC 2132722 PMID 9531558 . Vayssière B, Zalcman G, Mahé Y, Mirey G, Ligensa T, Weidner KM, Chardin P, Camonis J (Feb 2000). "Interaction of the Grb7 adapter protein with Rnd1, a new member of the Rho family" . FEBS Letters . 467 (1): 91–6. doi :10.1016/S0014-5793(99)01530-6 PMID 10664463 . S2CID 4901644 . Aoki J, Katoh H, Mori K, Negishi M (Nov 2000). "Rnd1, a novel rho family GTPase, induces the formation of neuritic processes in PC12 cells". Biochemical and Biophysical Research Communications . 278 (3): 604–8. doi :10.1006/bbrc.2000.3842 . PMID 11095956 . Rohm B, Rahim B, Kleiber B, Hovatta I, Püschel AW (Dec 2000). "The semaphorin 3A receptor may directly regulate the activity of small GTPases" . FEBS Letters . 486 (1): 68–72. doi :10.1016/S0014-5793(00)02240-7 PMID 11108845 . S2CID 7914214 . Nancy V, Callebaut I, El Marjou A, de Gunzburg J (Apr 2002). "The delta subunit of retinal rod cGMP phosphodiesterase regulates the membrane association of Ras and Rap GTPases" . The Journal of Biological Chemistry . 277 (17): 15076–84. doi :10.1074/jbc.M109983200 PMID 11786539 . Katoh H, Harada A, Mori K, Negishi M (May 2002). "Socius is a novel Rnd GTPase-interacting protein involved in disassembly of actin stress fibers" . Molecular and Cellular Biology . 22 (9): 2952–64. doi :10.1128/MCB.22.9.2952-2964.2002 . PMC 133765 PMID 11940653 . Hanzal-Bayer M, Renault L, Roversi P, Wittinghofer A, Hillig RC (May 2002). "The complex of Arl2-GTP and PDE delta: from structure to function" . The EMBO Journal . 21 (9): 2095–106. doi :10.1093/emboj/21.9.2095 . PMC 125981 PMID 11980706 . Oinuma I, Katoh H, Harada A, Negishi M (Jul 2003). "Direct interaction of Rnd1 with Plexin-B1 regulates PDZ-RhoGEF-mediated Rho activation by Plexin-B1 and induces cell contraction in COS-7 cells" . The Journal of Biological Chemistry . 278 (28): 25671–7. doi :10.1074/jbc.M303047200 PMID 12730235 . Oinuma I, Ishikawa Y, Katoh H, Negishi M (Aug 2004). "The Semaphorin 4D receptor Plexin-B1 is a GTPase activating protein for R-Ras". Science . 305 (5685): 862–5. Bibcode :2004Sci...305..862O . doi :10.1126/science.1097545 . PMID 15297673 . S2CID 39544623 . Harada A, Katoh H, Negishi M (May 2005). "Direct interaction of Rnd1 with FRS2 beta regulates Rnd1-induced down-regulation of RhoA activity and is involved in fibroblast growth factor-induced neurite outgrowth in PC12 cells" . The Journal of Biological Chemistry . 280 (18): 18418–24. doi :10.1074/jbc.M411356200 PMID 15738000 . Kim YS, Hori M, Yasuda K, Ozaki H (Dec 2005). "Differences in the gestational pattern of mRNA expression of the Rnd family in rat and human myometria". Comparative Biochemistry and Physiology A . 142 (4): 410–5. doi :10.1016/j.cbpa.2005.08.028 . PMID 16311049 .
