60S ribosomal protein L28

60S ribosomal protein L28 is a protein that in humans is encoded by the RPL28 gene.

RPL28
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 5AJ0, 4UG0, 4V6X, 4UJD, 4D67, 4D5Y, 4UJE, 4UJC
Identifiers
Aliases	RPL28, L28, ribosomal protein L28
External IDs	OMIM: 603638; MGI: 101839; HomoloGene: 768; GeneCards: RPL28; OMA:RPL28 - orthologs
EC number	3.6.5.3
Gene location (Human) Chr. Chromosome 19 (human) Band 19q13.42 Start 55,385,932 bp End 55,403,250 bp
Gene location (Mouse) Chr. Chromosome 7 (mouse) Band 7 A1|7 2.77 cM Start 4,795,873 bp End 4,798,065 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in superficial temporal artery oral cavity skin of thigh mucosa of paranasal sinus skin of hip trabecular bone lower lobe of lung human penis caput epididymis corpus epididymis Top expressed in urinary bladder yolk sac adrenal gland white adipose tissue bone marrow epiblast striatum of neuraxis uterus thymus spleen More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding RNA binding structural constituent of ribosome Cellular component cell body cytosol ribosome membrane intracellular anatomical structure dendrite cytoplasmic ribonucleoprotein granule cytosolic large ribosomal subunit extracellular exosome Biological process positive regulation of protein targeting to mitochondrion viral transcription SRP-dependent cotranslational protein targeting to membrane regulation of autophagy of mitochondrion translational initiation nuclear-transcribed mRNA catabolic process, nonsense-mediated decay rRNA processing protein biosynthesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6158 19943 Ensembl ENSG00000108107 ENSMUSG00000030432 UniProt P46779 P41105 RefSeq (mRNA) NM_000991 NM_001136134 NM_001136135 NM_001136136 NM_001136137 NM_001363697 NM_009081 RefSeq (protein) NP_000982 NP_001129606 NP_001129607 NP_001129608 NP_001129609 NP_001350626 NP_033107 Location (UCSC) Chr 19: 55.39 – 55.4 Mb Chr 7: 4.8 – 4.8 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Function

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L28E family of ribosomal proteins. It is located in the cytoplasm. Variable expression of this gene in colorectal cancers compared to adjacent normal tissues has been observed, although no correlation between the level of expression and the severity of the disease has been found. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.

External links

• Human RPL28 genome location and RPL28 gene details page in the UCSC Genome Browser.
• PDBe-KB provides an overview of all the structure information available in the PDB for Human 60S ribosomal protein L28

Further reading

• Wool IG, Chan YL, Glück A (1996). "Structure and evolution of mammalian ribosomal proteins". Biochem. Cell Biol. 73 (11–12): 933–47. doi:10.1139/o95-101. PMID 8722009.
• Brown JR, Daar IO, Krug JR, Maquat LE (1985). "Characterization of the functional gene and several processed pseudogenes in the human triosephosphate isomerase gene family". Mol. Cell. Biol. 5 (7): 1694–706. doi:10.1128/mcb.5.7.1694. PMC 367288. PMID 4022011.
• Kato S, Sekine S, Oh SW, et al. (1995). "Construction of a human full-length cDNA bank". Gene. 150 (2): 243–50. doi:10.1016/0378-1119(94)90433-2. PMID 7821789.
• Bortoluzzi S, d'Alessi F, Romualdi C, Danieli GA (2002). "Differential expression of genes coding for ribosomal proteins in different human tissues". Bioinformatics. 17 (12): 1152–7. doi:10.1093/bioinformatics/17.12.1152. PMID 11751223.
• Mammalian Gene Collection Program Team, Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proceedings of the National Academy of Sciences. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Kasai H, Nadano D, Hidaka E, et al. (2003). "Differential expression of ribosomal proteins in human normal and neoplastic colorectum". J. Histochem. Cytochem. 51 (5): 567–74. doi:10.1177/002215540305100502. PMID 12704204. S2CID 25865715.
• Odintsova TI, Müller EC, Ivanov AV, et al. (2004). "Characterization and analysis of posttranslational modifications of the human large cytoplasmic ribosomal subunit proteins by mass spectrometry and Edman sequencing". J. Protein Chem. 22 (3): 249–58. doi:10.1023/A:1025068419698. PMID 12962325. S2CID 10710245.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Villacé P, Marión RM, Ortín J (2004). "The composition of Staufen-containing RNA granules from human cells indicates their role in the regulated transport and translation of messenger RNAs". Nucleic Acids Res. 32 (8): 2411–20. doi:10.1093/nar/gkh552. PMC 419443. PMID 15121898.
• Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.