RPO may refer to:
In society:
- Railway post office, a mobile post office set up in a railway car
- Representation of People Ordinance, a set of Bangladeshi laws related to the formation of political parties
- Retail Post Outlet, a Canadian postal abbreviation
- Revenue Protection Officer, a UK railway employee who issues penalty fares
- Rural Planning Organization, U.S. state based, regional-level partnerships that facilitate transportation planning for state's rural areas
- Rzecznik Praw Obywatelskich, a Polish ombudsman
In automotive:
- Regular Production Option, an option produced by divisions of General Motors for its automobiles
In academia:
- Recursive path ordering, a well-ordering in term rewriting (computer science)
- Research Performing Organisations, a term used in European science policy
- Revilo Pendleton Oliver, an American professor of philology
In business:
- Recovery point objective, in business-continuity planning for computing
- Recruitment Process Outsourcing, a form of business-process outsourcing
- Regular Production Option, a General Motors standard coding system
In the armed forces:
- Regulating Petty Officer, a rate (rank) in the Royal Navy Police
- RPO-A Shmel (Bumblebee), a grenade launcher produced by Russia
In fiction:
- Ready Player One, a science-fiction dystopian novel by Ernest Cline
- Ready Player One (film), its film adaptation by Steven Spielberg.
In music:
- Rochester Philharmonic Orchestra, an orchestra in New York State
- Royal Philharmonic Orchestra, an orchestra in London, England
In entertainment:
- Rolie Polie Olie, a Canadian children's show on CBC Television (1998–2004)
In sport:
- Runs per over or run rate, a measure in the game of cricket
- Run-pass option, an offensive scheme in American football