40S ribosomal protein S26

40S ribosomal protein S26 is a protein that in humans is encoded by the RPS26 gene.

RPS26
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4UG0, 4V6X, 5A2Q, 5AJ0, 5FLX, 3J7R, 4D61, 4D5L, 4UJD, 3J7P, 4UJE, 4UJC
Identifiers
Aliases	RPS26, DBA10, S26, ribosomal protein S26, eS26
External IDs	OMIM: 603701; MGI: 1351628; HomoloGene: 37420; GeneCards: RPS26; OMA:RPS26 - orthologs
Gene location (Human) Chr. Chromosome 12 (human) Band 12q13.2 Start 56,041,351 bp End 56,044,697 bp
Gene location (Mouse) Chr. Chromosome 10 (mouse) Band 10|10 D3 Start 128,460,403 bp End 128,462,616 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte left adrenal cortex mucosa of transverse colon gastric mucosa right ovary right adrenal cortex right uterine tube anterior pituitary olfactory zone of nasal mucosa left uterine tube Top expressed in epiblast urinary bladder embryo bone marrow embryo uterus spleen adrenal gland thymus lens More reference expression data BioGPS n/a
Gene ontology Molecular function structural constituent of ribosome protein binding mRNA binding RNA binding cadherin binding Cellular component cytosol ribosome membrane intracellular anatomical structure cytosolic small ribosomal subunit small ribosomal subunit extracellular exosome nucleoplasm cytoplasm endoplasmic reticulum rough endoplasmic reticulum polysomal ribosome cytoplasmic side of rough endoplasmic reticulum membrane Biological process viral transcription SRP-dependent cotranslational protein targeting to membrane translational initiation nuclear-transcribed mRNA catabolic process, nonsense-mediated decay negative regulation of RNA splicing protein biosynthesis rRNA processing cytoplasmic translation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6231 27370 Ensembl ENSG00000197728 ENSMUSG00000025362 UniProt P62854 P62855 RefSeq (mRNA) NM_001029 NM_013765 RefSeq (protein) NP_001020 NP_038793 Location (UCSC) Chr 12: 56.04 – 56.04 Mb Chr 10: 128.46 – 128.46 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Function

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S26E family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.

Further reading

• Wool IG, Chan YL, Glück A (1996). "Structure and evolution of mammalian ribosomal proteins". Biochem. Cell Biol. 73 (11–12): 933–47. doi:10.1139/o95-101. PMID 8722009.
• Filipenko ML, Vladimirov SN, Muravlev AI, et al. (1994). "[Cloning cDNA of human S26 ribosomal protein and determination of its primary structure]". Bioorg. Khim. 20 (6): 644–9. PMID 7945460.
• Vincent S, Marty L, Fort P (1993). "S26 ribosomal protein RNA: an invariant control for gene regulation experiments in eucaryotic cells and tissues". Nucleic Acids Res. 21 (6): 1498. doi:10.1093/nar/21.6.1498. PMC 309346. PMID 8464749.
• Vladimirov SN, Ivanov AV, Karpova GG, et al. (1996). "Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry". Eur. J. Biochem. 239 (1): 144–9. doi:10.1111/j.1432-1033.1996.0144u.x. PMID 8706699.
• Filipenko ML, Vinichenko NA, Karpova GG, et al. (1998). "Isolation, structural analysis and mapping of the functional gene of human ribosomal protein S26". Gene. 211 (2): 287–92. doi:10.1016/S0378-1119(98)00108-5. PMID 9602156.
• Xu XR, Huang J, Xu ZG, et al. (2002). "Insight into hepatocellular carcinogenesis at transcriptome level by comparing gene expression profiles of hepatocellular carcinoma with those of corresponding noncancerous liver". Proc. Natl. Acad. Sci. U.S.A. 98 (26): 15089–94. doi:10.1073/pnas.241522398. PMC 64988. PMID 11752456.
• Ivanov AV, Malygin AA, Karpova GG (2002). "[Ribosomal protein binding with the first intron of the human ribosomal protein S26 pre-mRNA stimulates its interaction with proteins extracted from Hela cells]". Mol. Biol. (Mosk.). 36 (3): 503–10. PMID 12068637.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ivanov AV, Malygin AA, Karpova GG (2005). "Human ribosomal protein S26 suppresses the splicing of its pre-mRNA". Biochim. Biophys. Acta. 1727 (2): 134–40. doi:10.1016/j.bbaexp.2004.12.011. PMID 15716004.
• Yu Y, Ji H, Doudna JA, Leary JA (2005). "Mass spectrometric analysis of the human 40S ribosomal subunit: native and HCV IRES-bound complexes". Protein Sci. 14 (6): 1438–46. doi:10.1110/ps.041293005. PMC 2253395. PMID 15883184.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
• Tu LC, Yan X, Hood L, Lin B (2007). "Proteomics analysis of the interactome of N-myc downstream regulated gene 1 and its interactions with the androgen response program in prostate cancer cells" (PDF). Mol. Cell. Proteomics. 6 (4): 575–88. doi:10.1074/mcp.M600249-MCP200. PMID 17220478. S2CID 7203032.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

External links

• GeneReviews/NCBI/NIH/UW entry on Diamond-Blackfan Anemia
• Overview of all the structural information available in the PDB for UniProt: P62854 (40S ribosomal protein S26) at the PDBe-KB.