RSU1

Ras suppressor protein 1 is a protein that in humans is encoded by the RSU1 gene.

RSU1
Identifiers
Aliases	RSU1, RSP-1, Ras suppressor protein 1
External IDs	OMIM: 179555; MGI: 103040; HomoloGene: 7521; GeneCards: RSU1; OMA:RSU1 - orthologs
Gene location (Human) Chr. Chromosome 10 (human) Band 10p13 Start 16,590,611 bp End 16,817,463 bp
Gene location (Mouse) Chr. Chromosome 2 (mouse) Band 2|2 A1 Start 13,081,632 bp End 13,276,226 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in popliteal artery tibial arteries right coronary artery left coronary artery Descending thoracic aorta ascending aorta Achilles tendon monocyte saphenous vein stromal cell of endometrium Top expressed in genital tubercle granulocyte ascending aorta umbilical cord calvaria external carotid artery tail of embryo endothelial cell of lymphatic vessel left lung lobe right lung lobe More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component cytosol extracellular exosome focal adhesion Biological process positive regulation of GTPase activity regulation of cell-substrate adhesion signal transduction positive regulation of cell-substrate adhesion Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6251 20163 Ensembl ENSG00000148484 ENSMUSG00000026727 UniProt Q15404 Q01730 RefSeq (mRNA) NM_012425 NM_152724 NM_009105 RefSeq (protein) NP_036557 NP_689937 n/a Location (UCSC) Chr 10: 16.59 – 16.82 Mb Chr 2: 13.08 – 13.28 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a protein that is involved in the Ras signal transduction pathway, growth inhibition, and nerve-growth factor induced differentiation processes, as determined in mouse and human cell line studies. In mouse, the encoded protein was initially isolated based on its ability to inhibit v-Ras transformation. Multiple alternatively spliced transcript variants for this gene have been reported; one of these variants was found only in glioma tumors. RSU-1 has also been seen to act as a structural protein in integrin-mediated focal-adhesion complexes. It bind strongly to the protein PINCH.

Further reading

• Cutler ML, Bassin RH, Zanoni L, Talbot N (1992). "Isolation of rsp-1, a novel cDNA capable of suppressing v-Ras transformation". Mol. Cell. Biol. 12 (9): 3750–6. doi:10.1128/MCB.12.9.3750. PMC 360236. PMID 1508180.
• Tsuda T, Marinetti MR, Masuelli L, Cutler ML (1995). "The Ras suppressor RSU-1 localizes to 10p13 and its expression in the U251 glioblastoma cell line correlates with a decrease in growth rate and tumorigenic potential". Oncogene. 11 (2): 397–403. PMID 7624154.
• Matoba R, Okubo K, Hori N, et al. (1994). "The addition of 5'-coding information to a 3'-directed cDNA library improves analysis of gene expression". Gene. 146 (2): 199–207. doi:10.1016/0378-1119(94)90293-3. PMID 8076819.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Masuelli L, Cutler ML (1996). "Increased expression of the Ras suppressor Rsu-1 enhances Erk-2 activation and inhibits Jun kinase activation". Mol. Cell. Biol. 16 (10): 5466–76. doi:10.1128/MCB.16.10.5466. PMC 231547. PMID 8816460.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Chunduru S, Kawami H, Gullick R, et al. (2003). "Identification of an alternatively spliced RNA for the Ras suppressor RSU-1 in human gliomas". J. Neurooncol. 60 (3): 201–11. doi:10.1023/A:1021130620178. PMID 12510772. S2CID 34539.
• Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801. S2CID 23783563.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Aboulaich N, Vainonen JP, Strålfors P, Vener AV (2005). "Vectorial proteomics reveal targeting, phosphorylation and specific fragmentation of polymerase I and transcript release factor (PTRF) at the surface of caveolae in human adipocytes". Biochem. J. 383 (Pt 2): 237–48. doi:10.1042/BJ20040647. PMC 1134064. PMID 15242332.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Dougherty GW, Chopp T, Qi SM, Cutler ML (2005). "The Ras suppressor Rsu-1 binds to the LIM 5 domain of the adaptor protein PINCH1 and participates in adhesion-related functions". Exp. Cell Res. 306 (1): 168–79. doi:10.1016/j.yexcr.2005.01.025. PMID 15878342.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.