RsmW is a part of the Rsm/Csr family of non-coding RNAs (ncRNAs) discovered in Pseudomonas aeruginosa. It specifically binds to RsmA protein in vitro, restores biofilm production (possibly due to the interaction with RsmA) and partially complements the loss of RsmY and RsmZ in rsmY/rsmZ double mutant in regards to their contribution to swarming. Compared to RsmY and RsmZ its production is induced in high temperatures and rsmW is not transcriptionally activated by GacA.[1][2]
| RsmW sRNA | |
|---|---|
 Predicted secondary structure and sequence conservation of RsmW small RNA | |
| Identifiers | |
| Rfam | RF02809 |
| Other data | |
| Domain(s) | Bacteria |
| GO | GO:0071978 |
| SO | SO:0000370 |
| PDB structures | PDBe |
See also
editReferences
edit- ^ Miller CL, Romero M, Karna SL, Chen T, Heeb S, Leung KP (July 2016). "RsmW, Pseudomonas aeruginosa small non-coding RsmA-binding RNA upregulated in biofilm versus planktonic growth conditions". BMC Microbiology. 16 (1): 155. doi:10.1186/s12866-016-0771-y. PMC 4950607. PMID 27430253.
- ^ Wurtzel O, Yoder-Himes DR, Han K, Dandekar AA, Edelheit S, Greenberg EP, Sorek R, Lory S (September 2012). "The single-nucleotide resolution transcriptome of Pseudomonas aeruginosa grown in body temperature". PLOS Pathogens. 8 (9): e1002945. doi:10.1371/journal.ppat.1002945. PMC 3460626. PMID 23028334.
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