The Ružička large-ring synthesis or Ružička reaction or Ružička cyclization is an organic reaction in which a dicarboxylic acid is converted to a cyclic ketone via heating with a thorium oxide catalyst. The reaction is named after Lavoslav Ružička, who invented it in 1926.[1]
![The Ruzicka large-ring synthesis](http://upload.wikimedia.org/wikipedia/commons/thumb/5/59/Ru%C5%BEi%C4%8Dka-Cyclisierung.svg/400px-Ru%C5%BEi%C4%8Dka-Cyclisierung.svg.png)
The reaction has been applied in the synthesis of Exaltone, a low-toxicity synthetic musk.
References
edit- ^ L. Ruzicka; M. Stoll; H. Schinz (1926). "Zur Kenntnis des Kohlenstoffringes II. Synthese der carbocyclischen Ketone vom Zehner- bis zum Achtzehnerring". Helvetica Chimica Acta. 9 (1): 249–264. doi:10.1002/hlca.19260090130.