São Nicolau, meaning "Saint Nicholas" in Portuguese, may refer to the following places:
Brazil
edit- São Nicolau (Rio Grande do Sul), a municipality of the state of Rio Grande do Sul
- São Nicolau River, a river in the state of Piauí
Cape Verde
edit- São Nicolau, Cape Verde, an island
Portugal
edit- São Nicolau, Lisbon, a parish of the municipality of Lisbon
- São Nicolau, Porto, a parish of the municipality of Porto
- São Nicolau, Marco de Canaveses, a parish of the municipality of Marco de Canaveses
- São Nicolau, Mesão Frio, a parish of the municipality of Mesão Frio
- São Nicolau, Santarém, a parish of the municipality of Santarém.