S1PR5

Sphingosine-1-phosphate receptor 5 also known as S1PR5 is a human gene which encodes a G protein-coupled receptor which binds the lipid signaling molecule sphingosine 1-phosphate (S1P). Hence this receptor is also known as S1P₅.

S1PR5
Identifiers
Aliases	S1PR5, EDG8, Edg-8, S1P5, SPPR-1, SPPR-2, sphingosine-1-phosphate receptor 5
External IDs	OMIM: 605146; MGI: 2150641; HomoloGene: 11031; GeneCards: S1PR5; OMA:S1PR5 - orthologs
Gene location (Human) Chr. Chromosome 19 (human) Band 19p13.2 Start 10,512,742 bp End 10,517,931 bp
Gene location (Mouse) Chr. Chromosome 9 (mouse) Band 9|9 A3 Start 21,154,208 bp End 21,159,739 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte C1 segment internal globus pallidus inferior ganglion of vagus nerve corpus callosum substantia nigra skin of arm subthalamic nucleus blood putamen Top expressed in lumbar subsegment of spinal cord substantia nigra motor neuron deep cerebellar nuclei conjunctival fornix lateral geniculate nucleus anterior horn of spinal cord cornea pontine nuclei globus pallidus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function sphingosine-1-phosphate receptor activity G protein-coupled receptor activity signal transducer activity Cellular component integral component of membrane plasma membrane membrane Biological process regulation of neuron differentiation sphingosine-1-phosphate receptor signaling pathway signal transduction G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 53637 94226 Ensembl ENSG00000180739 ENSMUSG00000045087 UniProt Q9H228 Q91X56 RefSeq (mRNA) NM_030760 NM_001166215 NM_053190 RefSeq (protein) NP_001159687 NP_110387 NP_444420 Location (UCSC) Chr 19: 10.51 – 10.52 Mb Chr 9: 21.15 – 21.16 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Agonists

• A-971432
• Sphingosine 1-phosphate receptor agonists: a patent review (2010-2012)

Evolution

Paralogues for S1PR5 Gene

• S1PR1
• S1PR3
• S1PR2
• S1PR4
• LPAR1
• LPAR2
• GPR3
• LPAR3
• GPR12
• CNR1
• GPR6
• CNR2
• MC4R
• MC3R
• MC5R
• GPR119
• MC1R
• MC2R

See also

• Lysophospholipid receptor

Further reading

• Im DS, Heise CE, Ancellin N, O'Dowd BF, Shei GJ, Heavens RP, Rigby MR, Hla T, Mandala S, McAllister G, George SR, Lynch KR (May 2000). "Characterization of a novel sphingosine 1-phosphate receptor, Edg-8". The Journal of Biological Chemistry. 275 (19): 14281–6. doi:10.1074/jbc.275.19.14281. PMID 10799507.
• Malek RL, Toman RE, Edsall LC, Wong S, Chiu J, Letterle CA, Van Brocklyn JR, Milstien S, Spiegel S, Lee NH (Feb 2001). "Nrg-1 belongs to the endothelial differentiation gene family of G protein-coupled sphingosine-1-phosphate receptors". The Journal of Biological Chemistry. 276 (8): 5692–9. doi:10.1074/jbc.M003964200. PMID 11069896.
• Hla T (Apr 2001). "Sphingosine 1-phosphate receptors". Prostaglandins. 64 (1–4): 135–142. doi:10.1016/s0090-6980(01)00109-5. PMID 11331101.
• Im DS, Clemens J, Macdonald TL, Lynch KR (Nov 2001). "Characterization of the human and mouse sphingosine 1-phosphate receptor, S1P5 (Edg-8): structure-activity relationship of sphingosine1-phosphate receptors". Biochemistry. 40 (46): 14053–60. doi:10.1021/bi011606i. PMID 11705398.
• Takeda S, Kadowaki S, Haga T, Takaesu H, Mitaku S (Jun 2002). "Identification of G protein-coupled receptor genes from the human genome sequence". FEBS Letters. 520 (1–3): 97–101. doi:10.1016/S0014-5793(02)02775-8. PMID 12044878. S2CID 7116392.
• Niedernberg A, Scherer CR, Busch AE, Kostenis E (Oct 2002). "Comparative analysis of human and rat S1P(5) (edg8): differential expression profiles and sensitivities to antagonists". Biochemical Pharmacology. 64 (8): 1243–50. doi:10.1016/S0006-2952(02)01289-3. PMID 12234605.
• Kothapalli R, Kusmartseva I, Loughran TP (Dec 2002). "Characterization of a human sphingosine-1-phosphate receptor gene (S1P5) and its differential expression in LGL leukemia". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1579 (2–3): 117–23. doi:10.1016/S0167-4781(02)00529-8. PMID 12427546.
• Vogler R, Sauer B, Kim DS, Schäfer-Korting M, Kleuser B (Apr 2003). "Sphingosine-1-phosphate and its potentially paradoxical effects on critical parameters of cutaneous wound healing". The Journal of Investigative Dermatology. 120 (4): 693–700. doi:10.1046/j.1523-1747.2003.12096.x. PMID 12648236.
• Ulfig N, Briese M (2005). "Evidence for the presence of the sphingosine-1-phosphate receptor Edg-8 in human radial glial fibers". Acta Histochemica. 106 (5): 373–8. doi:10.1016/j.acthis.2004.08.002. PMID 15530552.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Otsuki T, Ota T, Nishikawa T, Hayashi K, Suzuki Y, Yamamoto J, Wakamatsu A, Kimura K, Sakamoto K, Hatano N, Kawai Y, Ishii S, Saito K, Kojima S, Sugiyama T, Ono T, Okano K, Yoshikawa Y, Aotsuka S, Sasaki N, Hattori A, Okumura K, Nagai K, Sugano S, Isogai T (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Research. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
• Van der Kam E, Turner S, van Bergeij J, Mueller R, Mezler M, Bespalov A, Hobson A, Harris CM, Rendenbach-Mueller B, Schoemaker H (Jun 2014). "The use of selective sphingosine-1-phosphate receptor 5 agonists for the treatment of neurodegenerative disorders such as alzheimer's disease and lysosomal storage diseases such as niemann-pick c disease". Alzheimer's & Dementia. 10: P281. doi:10.1016/j.jalz.2014.07.153. S2CID 54386805.
• Jenne CN, Enders A, Rivera R, Watson SR, Bankovich AJ, Pereira JP, Xu Y, Roots CM, Beilke JN, Banerjee A, Reiner SL, Miller SA, Weinmann AS, Goodnow CC, Lanier LL, Cyster JG, Chun J (Oct 2009). "T-bet-dependent S1P5 expression in NK cells promotes egress from lymph nodes and bone marrow". J Exp Med. 206 (11): 2469–81. doi:10.1084/jem.20090525. PMC 2768857. PMID 19808259.

External links

• "Lysophospholipid Receptors: S₁P₅". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
• Lysophospholipid+receptors at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.