SCSC is an acronym which may refer to:
- Safety-Critical Systems Club the UK's professional network for sharing knowledge about safety-critical systems
- Santa Clara Swim Club, a youth swim team in Santa Clara, CA.
- Sheffield City Swimming Club, a swimming club based in Sheffield
- Standing Council of Scottish Chiefs, an organization composed of the chiefs of many Scottish clans
- State Civil Service Commission
- Superconducting Super Collider, a cancelled particle accelerator
- South Carolina State College, the old name of South Carolina State University