Syndecan-3

Syndecan-3 is a protein that in humans is encoded by the SDC3 gene.

SDC3
Identifiers
Aliases	SDC3, SDCN, SYND3, syndecan 3
External IDs	OMIM: 186357; MGI: 1349163; HomoloGene: 7965; GeneCards: SDC3; OMA:SDC3 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) Band 1p35.2 Start 30,869,466 bp End 30,908,758 bp
Gene location (Mouse) Chr. Chromosome 4 (mouse) Band 4 D2.2|4 63.63 cM Start 130,519,848 bp End 130,553,630 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right adrenal cortex left adrenal cortex nucleus accumbens amygdala caudate nucleus anterior cingulate cortex hypothalamus putamen right frontal lobe left uterine tube Top expressed in calvaria stroma of bone marrow adrenal gland molar dentate gyrus of hippocampal formation granule cell body of femur mesenteric lymph nodes visual cortex olfactory epithelium primary visual cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding identical protein binding Cellular component integral component of membrane membrane plasma membrane lysosomal lumen Golgi lumen cell surface extracellular matrix collagen-containing extracellular matrix microspike Biological process glycosaminoglycan metabolic process retinoid metabolic process glycosaminoglycan catabolic process glycosaminoglycan biosynthetic process leukocyte migration cell migration Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9672 20970 Ensembl ENSG00000162512 ENSMUSG00000025743 UniProt O75056 Q64519 RefSeq (mRNA) NM_014654 NM_011520 RefSeq (protein) NP_055469 NP_035650 Location (UCSC) Chr 1: 30.87 – 30.91 Mb Chr 4: 130.52 – 130.55 Mb PubMed search
Wikidata
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Further reading

• Barillari G, Gendelman R, Gallo RC, Ensoli B (1993). "The Tat protein of human immunodeficiency virus type 1, a growth factor for AIDS Kaposi sarcoma and cytokine-activated vascular cells, induces adhesion of the same cell types by using integrin receptors recognizing the RGD amino acid sequence". Proc. Natl. Acad. Sci. U.S.A. 90 (17): 7941–5. Bibcode:1993PNAS...90.7941B. doi:10.1073/pnas.90.17.7941. PMC 47263. PMID 7690138.
• Raulo E, Chernousov MA, Carey DJ, et al. (1994). "Isolation of a neuronal cell surface receptor of heparin binding growth-associated molecule (HB-GAM). Identification as N-syndecan (syndecan-3)". J. Biol. Chem. 269 (17): 12999–3004. doi:10.1016/S0021-9258(18)99975-8. PMID 8175719.
• Chernousov MA, Carey DJ (1993). "N-syndecan (syndecan 3) from neonatal rat brain binds basic fibroblast growth factor". J. Biol. Chem. 268 (22): 16810–4. doi:10.1016/S0021-9258(19)85488-1. PMID 8344959.
• Albini A, Benelli R, Presta M, et al. (1996). "HIV-tat protein is a heparin-binding angiogenic growth factor". Oncogene. 12 (2): 289–97. PMID 8570206.
• Chernousov MA, Stahl RC, Carey DJ (1996). "Schwann cells secrete a novel collagen-like adhesive protein that binds N-syndecan". J. Biol. Chem. 271 (23): 13844–53. doi:10.1074/jbc.271.23.13844. PMID 8662884.
• Nakanishi T, Kadomatsu K, Okamoto T, et al. (1997). "Expression of syndecan-1 and -3 during embryogenesis of the central nervous system in relation to binding with midkine". J. Biochem. 121 (2): 197–205. PMID 9089390.
• Rusnati M, Coltrini D, Oreste P, et al. (1997). "Interaction of HIV-1 Tat protein with heparin. Role of the backbone structure, sulfation, and size". J. Biol. Chem. 272 (17): 11313–20. doi:10.1074/jbc.272.17.11313. PMID 9111037.
• Chang HC, Samaniego F, Nair BC, et al. (1997). "HIV-1 Tat protein exits from cells via a leaderless secretory pathway and binds to extracellular matrix-associated heparan sulfate proteoglycans through its basic region". AIDS. 11 (12): 1421–31. doi:10.1097/00002030-199712000-00006. PMID 9342064. S2CID 7648619.
• Asundi VK, Carey DJ (1997). "Phosphorylation of recombinant N-syndecan (syndecan 3) core protein". Biochem. Biophys. Res. Commun. 240 (2): 502–6. doi:10.1006/bbrc.1997.7684. PMID 9388509.
• Seki N, Ohira M, Nagase T, et al. (1998). "Characterization of cDNA clones in size-fractionated cDNA libraries from human brain". DNA Res. 4 (5): 345–9. doi:10.1093/dnares/4.5.345. PMID 9455484.
• Kinnunen T, Kaksonen M, Saarinen J, et al. (1998). "Cortactin-Src kinase signaling pathway is involved in N-syndecan-dependent neurite outgrowth". J. Biol. Chem. 273 (17): 10702–8. doi:10.1074/jbc.273.17.10702. PMID 9553134.
• Hsueh YP, Sheng M (1999). "Regulated expression and subcellular localization of syndecan heparan sulfate proteoglycans and the syndecan-binding protein CASK/LIN-2 during rat brain development". J. Neurosci. 19 (17): 7415–25. doi:10.1523/JNEUROSCI.19-17-07415.1999. PMC 6782500. PMID 10460248.
• Rusnati M, Tulipano G, Spillmann D, et al. (1999). "Multiple interactions of HIV-I Tat protein with size-defined heparin oligosaccharides". J. Biol. Chem. 274 (40): 28198–205. doi:10.1074/jbc.274.40.28198. PMID 10497173.
• Tyagi M, Rusnati M, Presta M, Giacca M (2001). "Internalization of HIV-1 tat requires cell surface heparan sulfate proteoglycans". J. Biol. Chem. 276 (5): 3254–61. doi:10.1074/jbc.M006701200. PMID 11024024.
• Koroll M, Rathjen FG, Volkmer H (2001). "The neural cell recognition molecule neurofascin interacts with syntenin-1 but not with syntenin-2, both of which reveal self-associating activity". J. Biol. Chem. 276 (14): 10646–54. doi:10.1074/jbc.M010647200. PMID 11152476.
• Hakansson S, Jacobs A, Caffrey M (2001). "Heparin binding by the HIV-1 tat protein transduction domain". Protein Sci. 10 (10): 2138–9. doi:10.1110/ps.23401. PMC 2374215. PMID 11567105.
• Erdman R, Stahl RC, Rothblum K, et al. (2002). "Schwann cell adhesion to a novel heparan sulfate binding site in the N-terminal domain of alpha 4 type V collagen is mediated by syndecan-3". J. Biol. Chem. 277 (9): 7619–25. doi:10.1074/jbc.M111311200. PMID 11751872.
• Alvarez K, Fadic R, Brandan E (2002). "Augmented synthesis and differential localization of heparan sulfate proteoglycans in Duchenne muscular dystrophy". J. Cell. Biochem. 85 (4): 703–13. doi:10.1002/jcb.10184. hdl:10533/173369. PMID 11968010. S2CID 20243469.