Mitochondrial 2-oxodicarboxylate carrier

Mitochondrial 2-oxodicarboxylate carrier also known as solute carrier family 25 member 21 (SLC25A21) is a protein that in humans is encoded by the SLC25A21 gene.

SLC25A21
Identifiers
Aliases	SLC25A21, ODC, ODC1, solute carrier family 25 member 21, MTDPS18
External IDs	OMIM: 607571; MGI: 2445059; HomoloGene: 6988; GeneCards: SLC25A21; OMA:SLC25A21 - orthologs
Gene location (Human) Chr. Chromosome 14 (human) Band 14q13.3 Start 36,677,921 bp End 37,172,606 bp
Gene location (Mouse) Chr. Chromosome 12 (mouse) Band 12|12 C1 Start 56,759,419 bp End 57,244,257 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gonad testicle stromal cell of endometrium gastric mucosa popliteal artery tibial arteries bone marrow right testis Achilles tendon smooth muscle tissue Top expressed in proximal tubule bone marrow right kidney hepatobiliary system liver human kidney spermatocyte lobe of liver morula embryo More reference expression data BioGPS n/a
Gene ontology Molecular function alpha-ketoglutarate transmembrane transporter activity dicarboxylic acid transmembrane transporter activity transmembrane transporter activity Cellular component membrane mitochondrion mitochondrial inner membrane integral component of membrane Biological process transmembrane transport lysine catabolic process alpha-ketoglutarate transport dicarboxylic acid transport mitochondrial transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 89874 217593 Ensembl ENSG00000183032 ENSMUSG00000035472 UniProt Q9BQT8 Q8BZ09 RefSeq (mRNA) NM_001171170 NM_030631 NM_001167976 NM_172577 RefSeq (protein) NP_001164641 NP_085134 NP_001161448 NP_766165 Location (UCSC) Chr 14: 36.68 – 37.17 Mb Chr 12: 56.76 – 57.24 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

It is a homolog of the S. cerevisiae ODC proteins, mitochondrial carriers that transport C5-C7 oxodicarboxylates across inner mitochondrial membranes. One of the species transported by ODC is 2-oxoadipate, a common intermediate in the catabolism of lysine, tryptophan, and hydroxylysine in mammals. Within mitochondria, 2-oxoadipate is converted into acetyl-CoA.

Further reading

• Fiermonte G, Dolce V, Palmieri L, Ventura M, Runswick MJ, Palmieri F, Walker JE (March 2001). "Identification of the human mitochondrial oxodicarboxylate carrier. Bacterial expression, reconstitution, functional characterization, tissue distribution, and chromosomal location". The Journal of Biological Chemistry. 276 (11): 8225–30. doi:10.1074/jbc.M009607200. PMID 11083877.
• Trynka G, Zhernakova A, Romanos J, Franke L, Hunt KA, Turner G, Bruinenberg M, Heap GA, Platteel M, Ryan AW, de Kovel C, Holmes GK, Howdle PD, Walters JR, Sanders DS, Mulder CJ, Mearin ML, Verbeek WH, Trimble V, Stevens FM, Kelleher D, Barisani D, Bardella MT, McManus R, van Heel DA, Wijmenga C (August 2009). "Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling". Gut. 58 (8): 1078–83. doi:10.1136/gut.2008.169052. PMID 19240061. S2CID 17111427.
• Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD (November 2009). "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip". American Journal of Human Genetics. 85 (5): 628–42. doi:10.1016/j.ajhg.2009.10.014. PMC 2775832. PMID 19913121.