Calcium-binding mitochondrial carrier protein SCaMC-1

Calcium-binding mitochondrial carrier protein SCaMC-1 is a protein that in humans is encoded by the SLC25A24 gene.

SLC25A24
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4N5X, 4ZCU, 4ZCV
Identifiers
Aliases	SLC25A24, APC1, SCAMC-1, solute carrier family 25 member 24, SCAMC1
External IDs	OMIM: 608744; MGI: 1917160; HomoloGene: 92693; GeneCards: SLC25A24; OMA:SLC25A24 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) Band 1p13.3 Start 108,134,043 bp End 108,200,849 bp
Gene location (Mouse) Chr. Chromosome 3 (mouse) Band 3|3 F3 Start 109,030,465 bp End 109,075,773 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in rectum duodenum islet of Langerhans monocyte Achilles tendon endometrium mucosa of transverse colon smooth muscle tissue placenta gallbladder Top expressed in left colon transitional epithelium of urinary bladder endothelial cell of lymphatic vessel stroma of bone marrow cumulus cell conjunctival fornix umbilical cord ileum human fetus endocardial cushion More reference expression data BioGPS n/a
Gene ontology Molecular function calcium ion binding ATP transmembrane transporter activity metal ion binding ADP transmembrane transporter activity transmembrane transporter activity Cellular component integral component of membrane membrane mitochondrion mitochondrial inner membrane Biological process regulation of cell death cellular response to calcium ion cellular response to oxidative stress mitochondrial transport transmembrane transport ATP transport ADP transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 29957 229731 Ensembl ENSG00000085491 ENSG00000284468 ENSMUSG00000040322 UniProt Q6NUK1 Q8BMD8 RefSeq (mRNA) NM_013386 NM_213651 NM_172685 RefSeq (protein) NP_037518 NP_998816 NP_766273 Location (UCSC) Chr 1: 108.13 – 108.2 Mb Chr 3: 109.03 – 109.08 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene encodes a carrier protein that transports ATP-Mg exchanging it for phosphate. Multiple transcript variants encoding different isoforms have been found for this gene.

Further reading

• Fiermonte G, De Leonardis F, Todisco S, Palmieri L, Lasorsa FM, Palmieri F (July 2004). "Identification of the mitochondrial ATP-Mg/Pi transporter. Bacterial expression, reconstitution, functional characterization, and tissue distribution" (PDF). The Journal of Biological Chemistry. 279 (29): 30722–30. doi:10.1074/jbc.M400445200. PMID 15123600.
• del Arco A, Satrústegui J (June 2004). "Identification of a novel human subfamily of mitochondrial carriers with calcium-binding domains". The Journal of Biological Chemistry. 279 (23): 24701–13. doi:10.1074/jbc.M401417200. PMID 15054102.
• Traba J, Del Arco A, Duchen MR, Szabadkai G, Satrústegui J (April 2012). "SCaMC-1 promotes cancer cell survival by desensitizing mitochondrial permeability transition via ATP/ADP-mediated matrix Ca(2+) buffering". Cell Death and Differentiation. 19 (4): 650–60. doi:10.1038/cdd.2011.139. PMC 3307981. PMID 22015608.
• Palmieri F (2013). "The mitochondrial transporter family SLC25: identification, properties and physiopathology". Molecular Aspects of Medicine. 34 (2–3): 465–84. doi:10.1016/j.mam.2012.05.005. PMID 23266187.
• Jia L, Young MF, Powell J, Yang L, Ho NC, Hotchkiss R, Robey PG, Francomano CA (January 2002). "Gene expression profile of human bone marrow stromal cells: high-throughput expressed sequence tag sequencing analysis". Genomics. 79 (1): 7–17. doi:10.1006/geno.2001.6683. PMID 11827452.

External links

• Overview of all the structural information available in the PDB for UniProt: Q6NUK1 (Human Calcium-binding mitochondrial carrier protein SCaMC-1) at the PDBe-KB.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.