Concentrative nucleoside transporter 1

Concentrative nucleoside transporter 1 (CNT1) is a protein that in humans is encoded by the SLC28A1 gene.

SLC28A1
Identifiers
Aliases	SLC28A1, CNT1, HCNT1, Concentrative nucleoside transporter 1, solute carrier family 28 member 1, URCTU
External IDs	OMIM: 606207; MGI: 3605073; HomoloGene: 37902; GeneCards: SLC28A1; OMA:SLC28A1 - orthologs
Gene location (Human) Chr. Chromosome 15 (human) Band 15q25.3 Start 84,884,654 bp End 84,945,798 bp
Gene location (Mouse) Chr. Chromosome 7 (mouse) Band 7|7 D3 Start 80,764,547 bp End 80,820,164 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of liver testicle human kidney duodenum mucosa of ileum jejunal mucosa kidney tubule muscle of thigh apex of heart renal medulla Top expressed in proximal tubule duodenum right kidney human kidney neck pharynx embryo primary oocyte bone marrow secondary oocyte More reference expression data BioGPS n/a
Gene ontology Molecular function nucleoside transmembrane transporter activity pyrimidine- and adenine-specific:sodium symporter activity nucleoside:sodium symporter activity Cellular component integral component of membrane plasma membrane membrane integral component of plasma membrane Biological process pyrimidine nucleobase transport nucleoside transport pyrimidine-containing compound transmembrane transport nucleoside transmembrane transport nucleobase-containing compound metabolic process purine nucleobase transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9154 434203 Ensembl ENSG00000156222 ENSMUSG00000025726 UniProt O00337 E9PXX9 RefSeq (mRNA) NM_001287761 NM_001287762 NM_004213 NM_201651 NM_001321721 NM_001321722 NM_001004184 RefSeq (protein) NP_001274690 NP_001274691 NP_001308650 NP_001308651 NP_004204 NP_964014 NP_001004184 Location (UCSC) Chr 15: 84.88 – 84.95 Mb Chr 7: 80.76 – 80.82 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

See also

• Concentrative nucleoside transporters
• Nucleoside transporters
• Solute carrier family

Further reading

• Ritzel MW, Ng AM, Yao SY, et al. (2001). "Recent molecular advances in studies of the concentrative Na+-dependent nucleoside transporter (CNT) family: identification and characterization of novel human and mouse proteins (hCNT3 and mCNT3) broadly selective for purine and pyrimidine nucleosides (system cib)". Mol. Membr. Biol. 18 (1): 65–72. doi:10.1080/09687680118530. PMID 11396613. S2CID 218896128.
• Ritzel MW, Yao SY, Ng AM, et al. (1999). "Molecular cloning, functional expression and chromosomal localization of a cDNA encoding a human Na+/nucleoside cotransporter (hCNT2) selective for purine nucleosides and uridine". Mol. Membr. Biol. 15 (4): 203–11. doi:10.3109/09687689709044322. PMID 10087507.
• Loewen SK, Ng AM, Yao SY, et al. (1999). "Identification of amino acid residues responsible for the pyrimidine and purine nucleoside specificities of human concentrative Na(+) nucleoside cotransporters hCNT1 and hCNT2". J. Biol. Chem. 274 (35): 24475–84. doi:10.1074/jbc.274.35.24475. PMID 10455109.
• Mata JF, García-Manteiga JM, Lostao MP, et al. (2001). "Role of the human concentrative nucleoside transporter (hCNT1) in the cytotoxic action of 5[Prime]-deoxy-5-fluorouridine, an active intermediate metabolite of capecitabine, a novel oral anticancer drug". Mol. Pharmacol. 59 (6): 1542–8. doi:10.1124/mol.59.6.1542. hdl:10171/21116. PMID 11353816.
• Lai Y, Bakken AH, Unadkat JD (2002). "Simultaneous expression of hCNT1-CFP and hENT1-YFP in Madin-Darby canine kidney cells. Localization and vectorial transport studies". J. Biol. Chem. 277 (40): 37711–7. doi:10.1074/jbc.M204986200. PMID 12097333.
• Alcorn J, Lu X, Moscow JA, McNamara PJ (2002). "Transporter gene expression in lactating and nonlactating human mammary epithelial cells using real-time reverse transcription-polymerase chain reaction". J. Pharmacol. Exp. Ther. 303 (2): 487–96. doi:10.1124/jpet.102.038315. PMID 12388627. S2CID 16195525.
• Molina-Arcas M, Bellosillo B, Casado FJ, et al. (2003). "Fludarabine uptake mechanisms in B-cell chronic lymphocytic leukemia". Blood. 101 (6): 2328–34. doi:10.1182/blood-2002-07-2236. PMID 12411296.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• García-Manteiga J, Molina-Arcas M, Casado FJ, et al. (2004). "Nucleoside transporter profiles in human pancreatic cancer cells: role of hCNT1 in 2',2'-difluorodeoxycytidine- induced cytotoxicity". Clin. Cancer Res. 9 (13): 5000–8. PMID 14581375.
• Loewen SK, Yao SY, Slugoski MD, et al. (2004). "Transport of physiological nucleosides and anti-viral and anti-neoplastic nucleoside drugs by recombinant Escherichia coli nucleoside-H(+) cotransporter (NupC) produced in Xenopus laevis oocytes". Mol. Membr. Biol. 21 (1): 1–10. doi:10.1080/0968768031000140836. PMID 14668133. S2CID 11973712.
• Gray JH, Mangravite LM, Owen RP, et al. (2004). "Functional and genetic diversity in the concentrative nucleoside transporter, CNT1, in human populations". Mol. Pharmacol. 65 (3): 512–9. doi:10.1124/mol.65.3.512. PMID 14978229. S2CID 1788715.
• Farré X, Guillén-Gómez E, Sánchez L, et al. (2004). "Expression of the nucleoside-derived drug transporters hCNT1, hENT1 and hENT2 in gynecologic tumors". Int. J. Cancer. 112 (6): 959–66. doi:10.1002/ijc.20524. PMID 15386342. S2CID 33828164.
• Lai Y, Lee EW, Ton CC, et al. (2005). "Conserved residues F316 and G476 in the concentrative nucleoside transporter 1 (hCNT1) affect guanosine sensitivity and membrane expression, respectively". Am. J. Physiol., Cell Physiol. 288 (1): C39–45. doi:10.1152/ajpcell.00192.2004. PMID 15456697. S2CID 27633580.
• Fernández-Veledo S, Jover R, Casado FJ, et al. (2007). "Transcription factors involved in the expression of SLC28 genes in human liver parenchymal cells". Biochem. Biophys. Res. Commun. 353 (2): 381–8. doi:10.1016/j.bbrc.2006.12.021. PMID 17187757.
• Slugoski MD, Loewen SK, Ng AM, et al. (2007). "Specific mutations in transmembrane helix 8 of human concentrative Na+/nucleoside cotransporter hCNT1 affect permeant selectivity and cation coupling". Biochemistry. 46 (6): 1684–93. doi:10.1021/bi061692s. PMID 17279631.
• Smith KM, Slugoski MD, Cass CE, et al. (2007). "Cation coupling properties of human concentrative nucleoside transporters hCNT1, hCNT2 and hCNT3". Mol. Membr. Biol. 24 (1): 53–64. doi:10.1080/09687860600942534. PMID 17453413. S2CID 20779608.
• Guallar JP, Cano-Soldado P, Aymerich I, et al. (2007). "Altered expression of nucleoside transporter genes (SLC28 and SLC29) in adipose tissue from HIV-1-infected patients". Antivir. Ther. (Lond.). 12 (6): 853–63. doi:10.1177/135965350701200601. PMID 17926640. S2CID 19447232.