Vesicular inhibitory amino acid transporter

Vesicular inhibitory amino acid transporter is a protein that in humans is encoded by the SLC32A1 gene.

SLC32A1
Identifiers
Aliases	SLC32A1, VGAT, VIAAT, solute carrier family 32 member 1
External IDs	OMIM: 616440; MGI: 1194488; HomoloGene: 56451; GeneCards: SLC32A1; OMA:SLC32A1 - orthologs
Gene location (Human) Chr. Chromosome 20 (human) Band 20q11.23 Start 38,724,486 bp End 38,729,372 bp
Gene location (Mouse) Chr. Chromosome 2 (mouse) Band 2|2 H1 Start 158,452,687 bp End 158,457,668 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in nucleus accumbens putamen prefrontal cortex caudate nucleus endothelial cell external globus pallidus cingulate gyrus anterior cingulate cortex middle temporal gyrus right frontal lobe Top expressed in dorsal tegmental nucleus nucleus accumbens nucleus of stria terminalis lateral septal nucleus superior colliculus globus pallidus central gray substance of midbrain medulla oblongata Rostral migratory stream olfactory tubercle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function glycine transmembrane transporter activity amino acid transmembrane transporter activity gamma-aminobutyric acid:proton symporter activity Cellular component integral component of membrane membrane synaptic vesicle plasma membrane clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane synapse inhibitory synapse synaptic vesicle membrane presynaptic active zone dendrite terminus dendrite cone cell pedicle intracellular organelle cell tip neuron projection neuron projection terminus cytoplasmic vesicle membrane cytoplasmic vesicle integral component of synaptic vesicle membrane GABA-ergic synapse Biological process amino acid transmembrane transport ageing ion transport gamma-aminobutyric acid transport neurotransmitter transport hippocampus development neurotransmitter secretion glycine transport neurotransmitter loading into synaptic vesicle Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 140679 22348 Ensembl ENSG00000101438 ENSMUSG00000037771 UniProt Q9H598 O35633 RefSeq (mRNA) NM_080552 NM_009508 RefSeq (protein) NP_542119 NP_033534 Location (UCSC) Chr 20: 38.72 – 38.73 Mb Chr 2: 158.45 – 158.46 Mb PubMed search
Wikidata
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The protein encoded by this gene is an integral membrane protein involved in gamma-aminobutyric acid (GABA) and glycine uptake into synaptic vesicles. The encoded protein is a member of amino acid/polyamine transporter family II.

See also

• Solute carrier family

Further reading

• McIntire SL, Reimer RJ, Schuske K, et al. (1997). "Identification and characterization of the vesicular GABA transporter". Nature. 389 (6653): 870–6. doi:10.1038/39908. PMID 9349821. S2CID 4404823.
• Kleiderlein JJ, Nisson PE, Jessee J, et al. (1999). "CCG repeats in cDNAs from human brain". Hum. Genet. 103 (6): 666–73. doi:10.1007/s004390050889. PMID 9921901. S2CID 23696667.
• Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. Bibcode:2001Natur.414..865D. doi:10.1038/414865a. PMID 11780052.
• Chessler SD, Simonson WT, Sweet IR, Hammerle LP (2002). "Expression of the vesicular inhibitory amino acid transporter in pancreatic islet cells: distribution of the transporter within rat islets". Diabetes. 51 (6): 1763–71. doi:10.2337/diabetes.51.6.1763. PMID 12031963.
• Jellali A, Stussi-Garaud C, Gasnier B, et al. (2002). "Cellular localization of the vesicular inhibitory amino acid transporter in the mouse and human retina". J. Comp. Neurol. 449 (1): 76–87. doi:10.1002/cne.10272. PMID 12115694. S2CID 27646744.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Geigerseder C, Doepner R, Thalhammer A, et al. (2003). "Evidence for a GABAergic system in rodent and human testis: local GABA production and GABA receptors". Neuroendocrinology. 77 (5): 314–23. doi:10.1159/000070897. hdl:11336/36231. PMID 12806177. S2CID 7652352.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.