CMP-sialic acid transporter

CMP-sialic acid transporter is a protein that in humans is encoded by the SLC35A1 gene.

SLC35A1
Identifiers
Aliases	SLC35A1, CDG2F, CMPST, CST, hCST, Solute carrier family 35 (CMP-sialic acid transporter), member A1, solute carrier family 35 member A1
External IDs	OMIM: 605634; MGI: 1345622; HomoloGene: 38181; GeneCards: SLC35A1; OMA:SLC35A1 - orthologs
Gene location (Human) Chr. Chromosome 6 (human) Band 6q15 Start 87,470,623 bp End 87,512,336 bp
Gene location (Mouse) Chr. Chromosome 4 (mouse) Band 4|4 A5 Start 34,663,257 bp End 34,687,438 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte rectum gonad right lung Achilles tendon granulocyte cerebellar hemisphere transverse colon mucosa of transverse colon endometrium Top expressed in conjunctival fornix left colon cornea submandibular gland corneal stroma epithelium of lens Paneth cell Epithelium of choroid plexus right kidney epithelium of stomach More reference expression data BioGPS n/a
Gene ontology Molecular function CMP-N-acetylneuraminate transmembrane transporter activity pyrimidine nucleotide-sugar transmembrane transporter activity sialic acid transmembrane transporter activity Cellular component integral component of membrane Golgi membrane Golgi apparatus integral component of plasma membrane membrane integral component of Golgi membrane Biological process CMP-N-acetylneuraminate transmembrane transport carbohydrate transport carbohydrate metabolic process pyrimidine nucleotide-sugar transmembrane transport sialic acid transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10559 24060 Ensembl ENSG00000164414 ENSMUSG00000028293 UniProt P78382 Q61420 RefSeq (mRNA) NM_006416 NM_001168398 NM_011895 RefSeq (protein) NP_001161870 NP_006407 NP_036025 Location (UCSC) Chr 6: 87.47 – 87.51 Mb Chr 4: 34.66 – 34.69 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

See also

• Solute carrier family

Further reading

• Wahlberg JE (1976). "Sensitization and testing of guinea pigs with nickel sulfate". Dermatologica. 152 (6): 321–30. doi:10.1159/000251278. PMID 964426.
• Harvey BE, Thomas P (1993). "Inhibition of CMP-sialic acid transport in human liver and colorectal cancer cell lines by a sialic acid nucleoside conjugate (KI-8110)". Biochem. Biophys. Res. Commun. 190 (2): 571–5. doi:10.1006/bbrc.1993.1086. PMID 8427599.
• Lennon G, Auffray C, Polymeropoulos M, Soares MB (1996). "The I.M.A.G.E. Consortium: an integrated molecular analysis of genomes and their expression". Genomics. 33 (1): 151–2. doi:10.1006/geno.1996.0177. PMID 8617505.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Aoki K, Ishida N, Kawakita M (2003). "Substrate recognition by nucleotide sugar transporters: further characterization of substrate recognition regions by analyses of UDP-galactose/CMP-sialic acid transporter chimeras and biochemical analysis of the substrate specificity of parental and chimeric transporters". J. Biol. Chem. 278 (25): 22887–93. doi:10.1074/jbc.M302620200. PMID 12682060.
• Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Martinez-Duncker I, Dupré T, Piller V, et al. (2005). "Genetic complementation reveals a novel human congenital disorder of glycosylation of type II, due to inactivation of the Golgi CMP-sialic acid transporter". Blood. 105 (7): 2671–6. doi:10.1182/blood-2004-09-3509. PMID 15576474. S2CID 13582151.
• Misaki R, Fujiyama K, Seki T (2006). "Expression of human CMP-N-acetylneuraminic acid synthetase and CMP-sialic acid transporter in tobacco suspension-cultured cell". Biochem. Biophys. Res. Commun. 339 (4): 1184–9. doi:10.1016/j.bbrc.2005.11.130. PMID 16343442.
• Zhao W, Chen TL, Vertel BM, Colley KJ (2006). "The CMP-sialic acid transporter is localized in the medial-trans Golgi and possesses two specific endoplasmic reticulum export motifs in its carboxyl-terminal cytoplasmic tail". J. Biol. Chem. 281 (41): 31106–18. doi:10.1074/jbc.M605564200. PMID 16923816.

External links

• GeneReviews/NCBI/NIH/UW entry on Congenital Disorders of Glycosylation Overview