UDP-xylose and UDP-N-acetylglucosamine transporter

UDP-xylose and UDP-N-acetylglucosamine transporter is a protein that in humans is encoded by the SLC35B4 gene.

SLC35B4
Identifiers
Aliases	SLC35B4, YEA, YEA4, solute carrier family 35 member B4
External IDs	OMIM: 610923; MGI: 1931249; HomoloGene: 5799; GeneCards: SLC35B4; OMA:SLC35B4 - orthologs
Gene location (Human) Chr. Chromosome 7 (human) Band 7q33 Start 134,289,332 bp End 134,316,930 bp
Gene location (Mouse) Chr. Chromosome 6 (mouse) Band 6|6 A3.3 Start 34,130,315 bp End 34,154,046 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cerebellar vermis middle temporal gyrus Brodmann area 23 endothelial cell placenta retinal pigment epithelium gonad tibia lateral nuclear group of thalamus superior frontal gyrus Top expressed in otic vesicle right kidney saccule otic placode zygote proximal tubule yolk sac human kidney secondary oocyte superior frontal gyrus More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding UDP-xylose transmembrane transporter activity GDP-fucose transmembrane transporter activity UDP-N-acetylglucosamine transmembrane transporter activity 3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity transmembrane transporter activity Cellular component integral component of membrane endoplasmic reticulum membrane integral component of Golgi membrane integral component of endoplasmic reticulum membrane Golgi apparatus Golgi membrane Biological process UDP-xylose transmembrane transport regulation of gluconeogenesis carbohydrate transport transmembrane transport GDP-fucose transmembrane transport UDP-N-acetylglucosamine transmembrane transport 3'-phospho-5'-adenylyl sulfate transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 84912 58246 Ensembl ENSG00000205060 ENSMUSG00000018999 UniProt Q969S0 Q8CIA5 RefSeq (mRNA) NM_032826 NM_021435 RefSeq (protein) NP_116215 NP_067410 Location (UCSC) Chr 7: 134.29 – 134.32 Mb Chr 6: 34.13 – 34.15 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

See also

• Solute carrier family

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology". Science. 300 (5620): 767–72. Bibcode:2003Sci...300..767S. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ashikov A, Routier F, Fuhlrott J, et al. (2005). "The human solute carrier gene SLC35B4 encodes a bifunctional nucleotide sugar transporter with specificity for UDP-xylose and UDP-N-acetylglucosamine". J. Biol. Chem. 280 (29): 27230–5. doi:10.1074/jbc.M504783200. PMID 15911612.
• Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
• Oh JH, Yang JO, Hahn Y, et al. (2006). "Transcriptome analysis of human gastric cancer". Mamm. Genome. 16 (12): 942–54. doi:10.1007/s00335-005-0075-2. PMID 16341674. S2CID 69278.
• Kobayashi T, Sleeman JE, Coughtrie MW, Burchell B (2006). "Molecular and functional characterization of microsomal UDP-glucuronic acid uptake by members of the nucleotide sugar transporter (NST) family". Biochem. J. 400 (2): 281–9. doi:10.1042/BJ20060429. PMC 1652819. PMID 16965264.