SLC35H1

SLC35H1
Identifiers
Aliases	SLC35H1, BA394O2.1, C20orf5, CGI-15, OVCOV1, solute carrier family 35 member C2, Solute carrier family 35 member H1
External IDs	MGI: 2385166; GeneCards: SLC35H1
Gene location (Human)
Chr.	Chromosome 20 (human)
End	46,364,458 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	165,129,789 bp
RNA expression pattern
	Top expressed in
	tendon of biceps brachii; ; right uterine tube; ; granulocyte; ; left lobe of thyroid gland; ; right lobe of thyroid gland; ; stromal cell of endometrium; ; right adrenal cortex; ; left adrenal cortex; ; right ovary; ; minor salivary glands;
	Top expressed in
	lacrimal gland; ; granulocyte; ; duodenum; ; right kidney; ; dentate gyrus of hippocampal formation granule cell; ; yolk sac; ; jejunum; ; superior frontal gyrus; ; primary visual cortex; ; muscle of thigh;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	antiporter activity; transmembrane transporter activity;
Cellular component	integral component of membrane; cis-Golgi network; endoplasmic reticulum-Golgi intermediate compartment membrane; membrane; endoplasmic reticulum-Golgi intermediate compartment; nucleoplasm; Golgi apparatus;
Biological process	protein O-linked fucosylation; fucosylation; negative regulation of gene expression; positive regulation of Notch signaling pathway; UDP-glucose transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	51006
	228875
	ENSG00000080189
	ENSMUSG00000017664
	Q9NQQ7
	Q8VCX2
NM_001281457; NM_001281458; NM_001281459; NM_001281460; NM_015945;
	NM_173073; NM_173179
NM_001252573; NM_001252574; NM_001252575; NM_144893; NM_001363015;
	NM_001363016
NP_001268386; NP_001268387; NP_001268388; NP_001268389; NP_057029;
	NP_775096; NP_775271
NP_001239502; NP_001239503; NP_001239504; NP_659142; NP_001349944;
	NP_001349945
	Wikidata
View/Edit Human	View/Edit Mouse

Solute carrier family 35 member H1 is a protein that in humans is encoded by the SLC35H1 gene (previously SLC35C2).^[5]^[6]^[7] This protein was originally thought to act as a GDP-fucose transporter like its homolog SLC35C1, but later research has suggested that this is not the case.^[8]

Oxygenation levels play an important role in the regulation of cellular invasiveness which occurs during early implantation when the trophoblast cells invade the uterus as well as during tumour progression and metastasis. This gene, which is regulated by oxygen tension, is induced in hypoxic trophoblast cells and is overexpressed in ovarian cancer. Two protein isoforms are encoded by transcript variants of this gene.^[7]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000080189 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000017664 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Lai CH, Chou CY, Ch'ang LY, Liu CS, Lin W (Aug 2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Res. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC 310876. PMID 10810093.
↑ Fossey SC, Mychaleckyj JC, Pendleton JK, Snyder JR, Bensen JT, Hirakawa S, Rich SS, Freedman BI, Bowden DW (Sep 2001). "A high-resolution 6.0-megabase transcript map of the type 2 diabetes susceptibility region on human chromosome 20". Genomics. 76 (1–3): 45–57. doi:10.1006/geno.2001.6584. PMID 11549316.
1 2 "Entrez Gene: SLC35C2 solute carrier family 35, member C2".
↑ "Solute carrier family 35 member H1". uniprot.org. UniProt consortium. Retrieved 2026-09-13.

Lash GE, Postovit LM, Matthews NE, et al. (2002). "Oxygen as a regulator of cellular phenotypes in pregnancy and cancer". Can. J. Physiol. Pharmacol. 80 (2): 103–9. doi:10.1139/y02-008. PMID 11934252.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Pires Martins R, Leach RE, Krawetz SA (2001). "Whole-body gene expression by data mining". Genomics. 72 (1): 34–42. doi:10.1006/geno.2000.6437. PMID 11247664.
Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. Bibcode:2001Natur.414..865D. doi:10.1038/414865a. PMID 11780052.
Leach R, Duniec-Dmuchowski Z, Tanaka T, et al. (2002). "Assignment of OVCOV1 (alias CGI-15) to human chromosome 20 band q13.1→q13.2 by fluorescent in situ hybridization". Cytogenet. Cell Genet. 94 (3–4): 252–3. doi:10.1159/000048828. PMID 11856893. S2CID 33594704.
Leach RE, Duniec-Dmuchowski ZM, Pesole G, et al. (2003). "Identification, molecular characterization, and tissue expression of OVCOV1". Mamm. Genome. 13 (11): 619–24. doi:10.1007/s00335-002-2185-4. PMID 12461647. S2CID 19423578.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

This article on a gene on human chromosome 20 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000080189 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000017664 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10810093-5] Lai CH, Chou CY, Ch'ang LY, Liu CS, Lin W (Aug 2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Res. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC 310876. PMID 10810093.

[pmid11549316-6] Fossey SC, Mychaleckyj JC, Pendleton JK, Snyder JR, Bensen JT, Hirakawa S, Rich SS, Freedman BI, Bowden DW (Sep 2001). "A high-resolution 6.0-megabase transcript map of the type 2 diabetes susceptibility region on human chromosome 20". Genomics. 76 (1–3): 45–57. doi:10.1006/geno.2001.6584. PMID 11549316.

[entrez-7] 1 2 "Entrez Gene: SLC35C2 solute carrier family 35, member C2".

[8] "Solute carrier family 35 member H1". uniprot.org. UniProt consortium. Retrieved 2026-09-13.

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References

Further reading