Solute carrier organic anion transporter family member 1B3

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Solute carrier organic anion transporter family member 1B3 (SLCO1B3) also known as organic anion-transporting polypeptide 1B3 (OATP1B3) is a protein that in humans is encoded by the SLCO1B3 gene.[5]

SLCO1B3
Identifiers
AliasesSLCO1B3, HBLRR, LST-2, LST-3TM13, LST3, OATP-8, OATP1B3, OATP8, SLC21A8, solute carrier organic anion transporter family member 1B3
External IDsOMIM: 605495; MGI: 1351899; HomoloGene: 75119; GeneCards: SLCO1B3; OMA:SLCO1B3 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_019844
NM_001349920

NM_020495
NM_178235

RefSeq (protein)

NP_062818
NP_001336849

NP_065241

Location (UCSC)Chr 12: 20.81 – 20.92 MbChr 6: 141.58 – 141.63 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

OATP1B3 is a 12-transmembrane domain influx transporter. Normally expressed in the liver, the transporter functions to uptake large, non-polar drugs and hormones from the portal vein.

Clinical significance

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OATP1B3 has also been identified as a transporter aberrantly expressed in prostate cancer and implicated in prostate cancer progression.[6] Increasing mRNA expression of OATP1B3 was also correlated to prostate cancer Gleason score.[7]

In addition, lower expression of OATP1B3 mRNA was also detected in testicular cancer.[7]

Substrates

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Small molecules that are transported by SLCO1B3 include:[8]

See also

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References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000111700Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030236Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: SLCO1B3 solute carrier organic anion transporter family, member 1B3".
  6. ^ Hamada A, Sissung T, Price DK, Danesi R, Chau CH, Sharifi N, Venzon D, Maeda K, Nagao K, Sparreboom A, Mitsuya H, Dahut WL, Figg WD (June 2008). "Effect of SLCO1B3 haplotype on testosterone transport and clinical outcome in caucasian patients with androgen-independent prostatic cancer". Clin. Cancer Res. 14 (11): 3312–8. doi:10.1158/1078-0432.CCR-07-4118. PMC 2701141. PMID 18519758.
  7. ^ a b Heather Pressler; Tristan M. Sissung; David Venzon; Douglas K. Price; William D. Figg (May 2011). "Expression of OATP Family Members in Hormone-Related Cancers: Potential Markers of Progression". PLOS ONE. 6 (5): e20372. Bibcode:2011PLoSO...620372P. doi:10.1371/journal.pone.0020372. PMC 3098289. PMID 21625523.
  8. ^ Hagenbuch B, Gui C (July 2008). "Xenobiotic transporters of the human organic anion transporting polypeptides (OATP) family". Xenobiotica. 38 (7–8): 778–801. doi:10.1080/00498250801986951. PMID 18668430. S2CID 85868712.

Further reading

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