Solute carrier organic anion transporter family member 2B1

Solute carrier organic anion transporter family member 2B1 also known as organic anion-transporting polypeptide 2B1 (OATP2B1) is a protein that in humans is encoded by the gene SLCO2B1.

SLCO2B1
Identifiers
Aliases	SLCO2B1, OATP-B, OATP2B1, OATPB, SLC21A9, solute carrier organic anion transporter family member 2B1
External IDs	OMIM: 604988; MGI: 1351872; HomoloGene: 21419; GeneCards: SLCO2B1; OMA:SLCO2B1 - orthologs
Gene location (Human) Chr. Chromosome 11 (human) Band 11q13.4 Start 75,100,563 bp End 75,206,549 bp
Gene location (Mouse) Chr. Chromosome 7 (mouse) Band 7|7 E1 Start 99,307,011 bp End 99,360,547 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of liver sural nerve upper lobe of left lung C1 segment lymph node spleen mucosa of ileum gallbladder right adrenal cortex appendix Top expressed in left lobe of liver mesenteric lymph nodes sciatic nerve lumbar subsegment of spinal cord subcutaneous adipose tissue white adipose tissue spleen skin of abdomen stroma of bone marrow extraocular muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function organic anion transmembrane transporter activity transporter activity sodium-independent organic anion transmembrane transporter activity bile acid transmembrane transporter activity Cellular component integral component of membrane plasma membrane membrane integral component of plasma membrane Biological process ion transport bile acid and bile salt transport sodium-independent organic anion transport transmembrane transport transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 11309 101488 Ensembl ENSG00000137491 ENSMUSG00000030737 UniProt O94956 Q8BXB6 RefSeq (mRNA) NM_007256 NM_001145211 NM_001145212 NM_001252530 NM_001252531 NM_175316 RefSeq (protein) NP_001138683 NP_001138684 NP_009187 NP_001239459 NP_001239460 NP_780525 Location (UCSC) Chr 11: 75.1 – 75.21 Mb Chr 7: 99.31 – 99.36 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

See also

• Solute carrier family

Further reading

• Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (6): 355–64. doi:10.1093/dnares/5.6.355. PMID 10048485.
• Tamai I, Nezu J, Uchino H, et al. (2000). "Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family". Biochem. Biophys. Res. Commun. 273 (1): 251–60. doi:10.1006/bbrc.2000.2922. PMID 10873595.
• St-Pierre MV, Hagenbuch B, Ugele B, et al. (2002). "Characterization of an organic anion-transporting polypeptide (OATP-B) in human placenta". J. Clin. Endocrinol. Metab. 87 (4): 1856–63. doi:10.1210/jcem.87.4.8431. PMID 11932330.
• Nozawa T, Nakajima M, Tamai I, et al. (2002). "Genetic polymorphisms of human organic anion transporters OATP-C (SLC21A6) and OATP-B (SLC21A9): allele frequencies in the Japanese population and functional analysis". J. Pharmacol. Exp. Ther. 302 (2): 804–13. doi:10.1124/jpet.302.2.804. PMID 12130747.
• Ugele B, St-Pierre MV, Pihusch M, et al. (2003). "Characterization and identification of steroid sulfate transporters of human placenta". Am. J. Physiol. Endocrinol. Metab. 284 (2): E390–8. doi:10.1152/ajpendo.00257.2002. PMID 12409283. S2CID 348962.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Hänggi E, Grundschober AF, Leuthold S, et al. (2006). "Functional analysis of the extracellular cysteine residues in the human organic anion transporting polypeptide, OATP2B1". Mol. Pharmacol. 70 (3): 806–17. doi:10.1124/mol.105.019547. PMID 16754786. S2CID 25002890.
• Grube M, Köck K, Karner S, et al. (2006). "Modification of OATP2B1-mediated transport by steroid hormones". Mol. Pharmacol. 70 (5): 1735–41. doi:10.1124/mol.106.026450. PMID 16908597. S2CID 6327839.