Small integral membrane protein 11 is a protein which in humans is encoded by the SMIM11 gene.[3][4]
| SMIM11 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Aliases | SMIM11, C21orf51, FAM165B, small integral membrane protein 11, SMIM11B, SMIM11A, small integral membrane protein 11A | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | HomoloGene: 129857; GeneCards: SMIM11; OMA:SMIM11 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Gene
editSMIM11 is located on the plus strand of chromosome 21 and has 4 exons.[4]
Expression
editThe expression of SMIM11 is highest in the brain, thyroid, and stomach, though it is also expressed in many other tissues.[4]
There are no known transcript variants or isoforms of SMIM11.[5]
Protein
editThe SMIM11 protein is 58 amino acids long. The theoretical molecular weight of this protein is 6kDa and the theoretical pI is 9.[6] The protein is localized in the cytoplasm and mitochondria, as well as focal adhesion points between the cells.[7][8]
Domains, Motifs, and Post-translational Modifications
editSMIM11 contains a transmembrane domain.[9] The protein also holds a dileucine motif. Post-translational modifications include ubiquitylation site, as well as two phosphorylated sites, one on a threonine and one on a serine[10][11]
The protein is composed mostly of alpha-helices.[12] The N-terminus of SMIM11 sticks out into the extracellular matrix, while the C-terminal end is located within the cytoplasm of the cell.[13]
Quaternary Structure and Protein Interactions
editExperimentally-determined protein interactions for SMIM11 have not yet been identified.[14]
Homology and Evolution
editParalogs
editNo paralogs or paralogous domains exist for SMIM11
Orthologs
editSMIM11 has a large number of orthologs. These orthologs range from other mammals to birds, reptiles, amphibians, and bony fish.[15]
References
edit- ^ a b c GRCh38: Ensembl release 89: ENSG00000205670 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "P58511 · SIM11_HUMAN". www.uniprot.org. UniProt. Retrieved 2022-12-23.
- ^ a b c "SMIM11 small integral membrane protein 11 [ Homo sapiens (human) ]". ncbi.nlm.nih.gov. National Center for Biotechnology Information, U.S. National Library of Medicine. Retrieved 2022-12-23.
- ^ "SMIM11A Protein Coding". genecards.org.
- ^ "Compute pI/Mw Tool Expasy". expasy.org.
- ^ "PSORT II Server". psort.hgc.jp.
- ^ "Immunohistochemistry of SMIM11A: The Human Protein Atlas". proteinatlas.org.
- ^ "Homo sapiens small integral membrane protein 11A (SMIM11A), mRNA". ncbi.nlm.nih.gov. NCBI (National Center for Biotechnology Information).
- ^ "iPTMnet Report for P58511 (SMIM11A)". research.bioinformatics.udel.edu.
- ^ "NetPhos 3.1 Server". cbs.dtu.dk.
- ^ "Phyre2 Results". sbg.bio.ic.ac.uk.
- ^ "TMHHM Server". cbs.dtu.dk.
- ^ "STRING FAM165B". string-db.org.
- ^ "NCBI Protein Blast". blast.ncbi.nlm.nih.gov.