SIK1

Serine/threonine-protein kinase SIK1 is an enzyme that in humans is encoded by the SIK1 gene.

SIK1
Identifiers
Aliases	SIK1, MSK, SIK, SNF1LK, EIEE30, salt inducible kinase 1, SIK-1, SIK1B, DEE30
External IDs	OMIM: 605705; MGI: 104754; HomoloGene: 136094; GeneCards: SIK1; OMA:SIK1 - orthologs
Gene location (Human) Chr. Chromosome 21 (human) Band 21q22.3 Start 43,414,483 bp End 43,427,131 bp
Gene location (Mouse) Chr. Chromosome 17 (mouse) Band 17 B1|17 17.25 cM Start 32,063,224 bp End 32,074,778 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gastric mucosa skin of abdomen skin of leg gallbladder bone marrow cells left ovary left uterine tube vagina right ovary upper lobe of left lung Top expressed in granulocyte decidua yolk sac lip muscle of thigh genital tubercle proximal tubule tail of embryo esophagus endocardial cushion More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding protein kinase activity cAMP response element binding protein binding 14-3-3 protein binding metal ion binding kinase activity protein serine/threonine kinase activity protein binding ATP binding protein kinase binding magnesium ion binding Cellular component cytoplasm nucleus nucleotide-activated protein kinase complex Biological process regulation of myotube differentiation cell differentiation intracellular signal transduction phosphorylation regulation of sodium ion transport rhythmic process cardiac muscle cell differentiation negative regulation of triglyceride biosynthetic process negative regulation of CREB transcription factor activity multicellular organism development protein phosphorylation negative regulation of gluconeogenesis regulation of mitotic cell cycle regulation of cell differentiation protein autophosphorylation cell cycle positive regulation of anoikis entrainment of circadian clock by photoperiod cellular response to hormone stimulus negative regulation of TOR signaling cellular response to glucose starvation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 150094 17691 Ensembl ENSG00000142178 ENSMUSG00000024042 UniProt P57059 Q60670 RefSeq (mRNA) NM_173354 NM_010831 RefSeq (protein) NP_001307572 NP_034961 Location (UCSC) Chr 21: 43.41 – 43.43 Mb Chr 17: 32.06 – 32.07 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

See also

• Serine/threonine-protein kinase
• SIK2

Further reading

• Takemori H, Kajimura J, Okamoto M (2007). "TORC-SIK cascade regulates CREB activity through the basic leucine zipper domain". FEBS J. 274 (13): 3202–9. doi:10.1111/j.1742-4658.2007.05889.x. PMID 17565599. S2CID 30323449.
• Al-Hakim AK, Göransson O, Deak M, et al. (2006). "14-3-3 cooperates with LKB1 to regulate the activity and localization of QSK and SIK". J. Cell Sci. 118 (Pt 23): 5661–73. doi:10.1242/jcs.02670. PMID 16306228. S2CID 17404931.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Lizcano JM, Göransson O, Toth R, et al. (2005). "LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1". EMBO J. 23 (4): 833–43. doi:10.1038/sj.emboj.7600110. PMC 381014. PMID 14976552.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Hattori M, Fujiyama A, Taylor TD, et al. (2000). "The DNA sequence of human chromosome 21". Nature. 405 (6784): 311–9. Bibcode:2000Natur.405..311H. doi:10.1038/35012518. PMID 10830953.
• Nishimura Y, Hayashi M, Inada H, Tanaka T (1999). "Molecular cloning and characterization of mammalian homologues of vesicle-associated membrane protein-associated (VAMP-associated) proteins". Biochem. Biophys. Res. Commun. 254 (1): 21–6. doi:10.1006/bbrc.1998.9876. PMID 9920726.