NHP2L1

NHP2-like protein 1 is a protein that in humans is encoded by the SNU13 gene.

SNU13
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1E7K, 2JNB, 2OZB, 3SIU, 3SIV, 3JCR
Identifiers
Aliases	SNU13, 15.5K, FA-1, FA1, NHPX, OTK27, SNRNP15-5, SPAG12, SSFA1, NHP2L1, SNU13 homolog, small nuclear ribonucleoprotein (U4/U6.U5), small nuclear ribonucleoprotein 13
External IDs	OMIM: 601304; MGI: 893586; HomoloGene: 3672; GeneCards: SNU13; OMA:SNU13 - orthologs
Gene location (Human) Chr. Chromosome 22 (human) Band 22q13.2 Start 41,673,933 bp End 41,690,504 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in beta cell prefrontal cortex hypothalamus right frontal lobe muscle of thigh right ventricle stromal cell of endometrium left testis right auricle Brodmann area 9 n/a More reference expression data BioGPS n/a
Gene ontology Molecular function U3 snoRNA binding ATPase binding U4 snRNA binding U4atac snRNA binding protein binding snoRNA binding RNA binding box C/D RNA binding Cellular component nucleoplasm spliceosomal complex nucleus small-subunit processome U4/U6 x U5 tri-snRNP complex nucleolus dense fibrillar component cytosolic large ribosomal subunit precatalytic spliceosome box C/D RNP complex U4atac snRNP protein-containing complex U2-type precatalytic spliceosome ribonucleoprotein complex Biological process mRNA processing ribosome biogenesis mRNA splicing, via spliceosome RNA splicing maturation of LSU-rRNA maturation of SSU-rRNA protein biosynthesis rRNA processing single fertilization box C/D snoRNP assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4809 20826 Ensembl ENSG00000100138 ENSMUSG00000063480 UniProt P55769 Q9D0T1 RefSeq (mRNA) NM_001003796 NM_005008 NM_011482 RefSeq (protein) NP_001003796 NP_004999 NP_035612 Location (UCSC) Chr 22: 41.67 – 41.69 Mb n/a PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Function

Originally named because of its sequence similarity to the Saccharomyces cerevisiae NHP2 (non-histone protein 2), this protein appears to be a highly conserved nuclear protein that is a component of the [U4/U6.U5] tri-snRNP. It binds to the 5' stem-loop of U4 snRNA. Two transcript variants encoding the same protein have been found for this gene.

Interactions

SNU13 has been shown to interact with RAD17.

Further reading

• Nottrott S, Hartmuth K, Fabrizio P, Urlaub H, Vidovic I, Ficner R, Lührmann R (Nov 1999). "Functional interaction of a novel 15.5kD [U4/U6.U5] tri-snRNP protein with the 5' stem-loop of U4 snRNA". The EMBO Journal. 18 (21): 6119–33. doi:10.1093/emboj/18.21.6119. PMC 1171676. PMID 10545122.
• Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP (Dec 1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi:10.1038/990031. PMID 10591208.
• Chang MS, Sasaki H, Campbell MS, Kraeft SK, Sutherland R, Yang CY, Liu Y, Auclair D, Hao L, Sonoda H, Ferland LH, Chen LB (Dec 1999). "HRad17 colocalizes with NHP2L1 in the nucleolus and redistributes after UV irradiation". The Journal of Biological Chemistry. 274 (51): 36544–9. doi:10.1074/jbc.274.51.36544. PMID 10593953.
• Vidovic I, Nottrott S, Hartmuth K, Lührmann R, Ficner R (Dec 2000). "Crystal structure of the spliceosomal 15.5kD protein bound to a U4 snRNA fragment". Molecular Cell. 6 (6): 1331–42. doi:10.1016/S1097-2765(00)00131-3. hdl:11858/00-001M-0000-0012-F75C-F. PMID 11163207.
• Andersen JS, Lyon CE, Fox AH, Leung AK, Lam YW, Steen H, Mann M, Lamond AI (Jan 2002). "Directed proteomic analysis of the human nucleolus". Current Biology. 12 (1): 1–11. Bibcode:2002CBio...12....1A. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298.
• Leung AK, Lamond AI (May 2002). "In vivo analysis of NHPX reveals a novel nucleolar localization pathway involving a transient accumulation in splicing speckles". The Journal of Cell Biology. 157 (4): 615–29. doi:10.1083/jcb.200201120. PMC 2173864. PMID 12011111.
• Watkins NJ, Dickmanns A, Lührmann R (Dec 2002). "Conserved stem II of the box C/D motif is essential for nucleolar localization and is required, along with the 15.5K protein, for the hierarchical assembly of the box C/D snoRNP". Molecular and Cellular Biology. 22 (23): 8342–52. doi:10.1128/MCB.22.23.8342-8352.2002. PMC 134055. PMID 12417735.
• Scherl A, Couté Y, Déon C, Callé A, Kindbeiter K, Sanchez JC, Greco A, Hochstrasser D, Diaz JJ (Nov 2002). "Functional proteomic analysis of human nucleolus". Molecular Biology of the Cell. 13 (11): 4100–9. doi:10.1091/mbc.E02-05-0271. PMC 133617. PMID 12429849.
• Collins JE, Wright CL, Edwards CA, Davis MP, Grinham JA, Cole CG, Goward ME, Aguado B, Mallya M, Mokrab Y, Huckle EJ, Beare DM, Dunham I (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biology. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802.
• Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI, Mann M (Jan 2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.
• Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (Sep 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.