Sp2 transcription factor

Transcription factor Sp2 is a protein that in humans is encoded by the SP2 gene.

SP2
Identifiers
Aliases	SP2, Sp2, 4930480I16Rik, mKIAA0048, Sp2 transcription factor
External IDs	OMIM: 601801; MGI: 1926162; HomoloGene: 2340; GeneCards: SP2; OMA:SP2 - orthologs
Gene location (Human) Chr. Chromosome 17 (human) Band 17q21.32 Start 47,896,150 bp End 47,928,957 bp
Gene location (Mouse) Chr. Chromosome 11 (mouse) Band 11|11 D Start 96,844,167 bp End 96,873,785 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte buccal mucosa cell granulocyte right testis left testis gastrocnemius muscle popliteal artery muscle of thigh tibial arteries monocyte Top expressed in granulocyte tail of embryo genital tubercle yolk sac zygote muscle of thigh thymus neural layer of retina mesenteric lymph nodes epiblast More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding histone deacetylase binding protein binding metal ion binding nucleic acid binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription repressor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus Biological process regulation of transcription by RNA polymerase II regulation of transcription, DNA-templated immune response transcription, DNA-templated multicellular organism growth negative regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6668 78912 Ensembl ENSG00000167182 ENSMUSG00000018678 UniProt Q02086 Q9BRW5 Q9D2H6 RefSeq (mRNA) NM_003110 NM_001080964 NM_030220 NM_001363225 NM_001363226 RefSeq (protein) NP_003101 NP_001074433 NP_084496 NP_001350154 NP_001350155 Location (UCSC) Chr 17: 47.9 – 47.93 Mb Chr 11: 96.84 – 96.87 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene encodes a member of the Sp subfamily of Sp/XKLF transcription factors. Sp family proteins are sequence-specific DNA-binding proteins characterized by an amino-terminal trans-activation domain and three carboxy-terminal zinc finger motifs. This protein contains the least conserved DNA-binding domain within the Sp subfamily of proteins, and its DNA sequence specificity differs from the other Sp proteins. It localizes primarily within subnuclear foci associated with the nuclear matrix, and can activate or in some cases repress expression from different promoters.

Interactions

Sp2 transcription factor has been shown to interact with E2F1.

Further reading

• Philipsen S, Suske G (1999). "A tale of three fingers: the family of mammalian Sp/XKLF transcription factors". Nucleic Acids Res. 27 (15): 2991–3000. doi:10.1093/nar/27.15.2991. PMC 148522. PMID 10454592.
• Nomura N, Nagase T, Miyajima N, Sazuka T, Tanaka A, Sato S, Seki N, Kawarabayasi Y, Ishikawa K, Tabata S (1995). "Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 1 (5): 223–9. doi:10.1093/dnares/1.5.223. PMID 7584044.
• Rotheneder H, Geymayer S, Haidweger E (2000). "Transcription factors of the Sp1 family: interaction with E2F and regulation of the murine thymidine kinase promoter". J. Mol. Biol. 293 (5): 1005–15. doi:10.1006/jmbi.1999.3213. PMID 10547281.
• Moorefield KS, Fry SJ, Horowitz JM (2004). "Sp2 DNA binding activity and trans-activation are negatively regulated in mammalian cells". J. Biol. Chem. 279 (14): 13911–24. doi:10.1074/jbc.M313589200. PMID 14726517.
• Phan D, Cheng CJ, Galfione M, Vakar-Lopez F, Tunstead J, Thompson NE, Burgess RR, Najjar SM, Yu-Lee LY, Lin SH (2004). "Identification of Sp2 as a transcriptional repressor of carcinoembryonic antigen-related cell adhesion molecule 1 in tumorigenesis". Cancer Res. 64 (9): 3072–8. doi:10.1158/0008-5472.CAN-03-3730. PMID 15126343.
• Phillips RJ, Tyson-Capper Née Pollard AJ, Bailey J, Robson SC, Europe-Finner GN (2005). "Regulation of expression of the chorionic gonadotropin/luteinizing hormone receptor gene in the human myometrium: involvement of specificity protein-1 (Sp1), Sp3, Sp4, Sp-like proteins, and histone deacetylases". J. Clin. Endocrinol. Metab. 90 (6): 3479–90. doi:10.1210/jc.2004-1962. PMID 15788387.
• Lee YC, Higashi Y, Luu C, Shimizu C, Strott CA (2005). "Sp1 elements in SULT2B1b promoter and 5'-untranslated region of mRNA: Sp1/Sp2 induction and augmentation by histone deacetylase inhibition". FEBS Lett. 579 (17): 3639–45. Bibcode:2005FEBSL.579.3639L. doi:10.1016/j.febslet.2005.05.041. PMID 15953604. S2CID 22203267.
• Simmons SO, Horowitz JM (2006). "Nkx3.1 binds and negatively regulates the transcriptional activity of Sp-family members in prostate-derived cells". Biochem. J. 393 (Pt 1): 397–409. doi:10.1042/BJ20051030. PMC 1383699. PMID 16201967.
• Moorefield KS, Yin H, Nichols TD, Cathcart C, Simmons SO, Horowitz JM (2006). "Sp2 localizes to subnuclear foci associated with the nuclear matrix". Mol. Biol. Cell. 17 (4): 1711–22. doi:10.1091/mbc.E05-11-1063. PMC 1415311. PMID 16467376.
• Das A, Fernandez-Zapico ME, Cao S, Yao J, Fiorucci S, Hebbel RP, Urrutia R, Shah VH (2007). "Disruption of an SP2/KLF6 repression complex by SHP is required for farnesoid X receptor-induced endothelial cell migration" (PDF). J. Biol. Chem. 281 (51): 39105–13. doi:10.1074/jbc.M607720200. PMID 17071613.

External links

• Sp2+Transcription+Factor at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• FactorBook SP2