Spermatogenesis associated 13

Spermatogenesis associated 13 is a protein that in humans is encoded by the SPATA13 gene.

SPATA13
Identifiers
Aliases	SPATA13, ARHGEF29, ASEF2, spermatogenesis associated 13
External IDs	OMIM: 613324; MGI: 104838; HomoloGene: 19482; GeneCards: SPATA13; OMA:SPATA13 - orthologs
Gene location (Mouse) Chr. Chromosome 14 (mouse) Band 14 D1|14 31.77 cM Start 60,871,450 bp End 61,002,005 bp
Gene ontology Molecular function protein binding guanyl-nucleotide exchange factor activity identical protein binding Cellular component cytoplasm filopodium ruffle membrane plasma membrane cell projection membrane lamellipodium nucleoplasm cytosol Biological process filopodium assembly regulation of Rho protein signal transduction regulation of cell migration cell migration lamellipodium assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 221178 219140 Ensembl n/a ENSMUSG00000021990 UniProt Q96N96 Q5DU57 RefSeq (mRNA) NM_001166271 NM_001286792 NM_001286793 NM_001286794 NM_001286795 NM_153023 NM_001033272 NM_001310594 RefSeq (protein) NP_001159743 NP_001273721 NP_001273722 NP_001273723 NP_001273724 NP_694568 NP_694568.1 NP_001028444 NP_001297523 NP_001391878 NP_001391879 NP_001391880 NP_001391881 NP_001391882 NP_001391883 NP_001391893 Location (UCSC) n/a Chr 14: 60.87 – 61 Mb PubMed search
Wikidata
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Further reading

• Kawasaki Y, Sagara M, Shibata Y, Shirouzu M, Yokoyama S, Akiyama T (December 2007). "Identification and characterization of Asef2, a guanine-nucleotide exchange factor specific for Rac1 and Cdc42". Oncogene. 26 (55): 7620–267. doi:10.1038/sj.onc.1210574. PMID 17599059.
• Sagara M, Kawasaki Y, Iemura SI, Natsume T, Takai Y, Akiyama T (March 2009). "Asef2 and Neurabin2 cooperatively regulate actin cytoskeletal organization and are involved in HGF-induced cell migration". Oncogene. 28 (10): 1357–65. doi:10.1038/onc.2008.478. PMID 19151759.
• Ding H, Xu Y, Bao X, Wang X, Cui G, Wang W, Hui R, Wang DW (January 2010). "Confirmation of genomewide association signals in Chinese Han population reveals risk loci for ischemic stroke". Stroke. 41 (1): 177–80. doi:10.1161/STROKEAHA.109.567099. PMID 19910543.
• Bristow JM, Sellers MH, Majumdar D, Anderson B, Hu L, Webb DJ (December 2009). "The Rho-family GEF Asef2 activates Rac to modulate adhesion and actin dynamics and thereby regulate cell migration". J. Cell Sci. 122 (Pt 24): 4535–46. doi:10.1242/jcs.053728. PMC 2787464. PMID 19934221.
• Jean L, Majumdar D, Shi M, Hinkle LE, Diggins NL, Ao M, Broussard JA, Evans JC, Choma DP, Webb DJ (December 2013). "Activation of Rac by Asef2 promotes myosin II-dependent contractility to inhibit cell migration on type I collagen". J. Cell Sci. 126 (Pt 24): 5585–97. doi:10.1242/jcs.131060. PMC 3860307. PMID 24144700.