This article may be too technical for most readers to understand.(August 2024) |
Famiraprinium (also known as SR-95103) is a GABAA receptor antagonist used in scientific research.[1]
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Names | |
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IUPAC name
4-(6-Imino-5-methyl-3-phenylpyridazin-1-yl)butanoic acid
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Other names
SR-95103
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Identifiers | |
3D model (JSmol)
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ChEMBL | |
ChemSpider | |
PubChem CID
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UNII | |
CompTox Dashboard (EPA)
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Properties | |
C15H17N3O2 | |
Molar mass | 271.320 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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It antagonizes certain GABAA receptors with an inhibition constant of 2.2 μM.[2]
Effects
editLike other GABA antagonists, it triggers epilepsy-like symptoms. These effects can be antagonized by GABAA agonists like muscimol, proving it is an antagonist.[3]
References
edit- ^ Schmitt, P.; Di Scala, G.; Brandao, M. L.; Karli, P. (1985-11-05). "Behavioral effects of microinjections of SR 95103, a new GABA-A antagonist, into the medial hypothalamus or the mesencephalic central gray". European Journal of Pharmacology. 117 (2): 149–158. doi:10.1016/0014-2999(85)90599-0. ISSN 0014-2999. PMID 3000802.
- ^ Chambon, J. P.; Feltz, P.; Heaulme, M.; Restle, S.; Schlichter, R.; Biziere, K.; Wermuth, C. G. (March 1985). "An arylaminopyridazine derivative of gamma-aminobutyric acid (GABA) is a selective and competitive antagonist at the GABAA receptor site". Proceedings of the National Academy of Sciences of the United States of America. 82 (6): 1832–1836. doi:10.1073/pnas.82.6.1832. ISSN 0027-8424. PMC 397367. PMID 2984669.
- ^ Santucci, V.; Fournier, M.; Chambon, J. P.; Biziere, K. (1985-08-15). "Electroencephalographic study of SR 95103, a GABAA antagonist: interaction with inhibitory amino acids and muscimol". European Journal of Pharmacology. 114 (2): 219–222. doi:10.1016/0014-2999(85)90630-2. ISSN 0014-2999. PMID 2995080.